About this Research Topic
With the introduction of nanotechnology in pharmaceutical sciences, nanocarrier development has become a viable alternative for drug delivery for the treatment of various diseases. However, despite successes at a laboratory scale, pharmaceutical formulation eventually fails when scaled up to an industrial level. The practical hindrance associated with these is the use of synthetic chemistry approaches and toxic components which renders the formulation clinically unsafe. In addition to this, employing sophisticated formulation methodologies increases the overall cost of treatment, and critical issues like ‘dose dumping’ cause a lack of patient adherence and acceptability. Regardless of these problems, many prospective nano-medicines have been used successfully in the market for applications ranging from day-to-day skincare to chronic diseases like cancer.
With an exponential increase in the use of biocompatible materials for the development of novel nanocarriers, the above challenges are anticipated to get corrected. Therefore, a need arises to develop novel drug delivery technologies which could make use of some established nano-based approaches and integrating them with newer ones. They possess a vast potential to provide combinative therapy by employing the use of drugs/active molecules with different solubilities and mechanisms. They can allow for the reduction in the effective dosage of the drugs/active molecules, decreased drug-related side effects, and the provision of sustained/controlled release profiles which can all shorten the duration of therapy for chronic long-term diseases. They can also provide options for a better prognosis/diagnosis of a specific disease, which can further help in designing a better therapeutic regimen. The use of integrative drug delivery approaches can also help to improve the formulation methodology and other attributes, e.g., time and method of preparation, amount of constituents used, use of agitation (temperature, heat, sonication, etc.), and stability in different media.
In recent times, the use of biocompatible excipients or nanocarriers has become thrust in the area of pharmaceutical drug delivery. This research specifically deals with studies showcasing the potential of self-assembly based nanocarriers made up of biocompatible inclusions or modifications. Examples of such nanocarriers and drug delivery technologies include but not limited to- Liposomes, Niosomes, Solid-Lipid nanoparticles, Micelles, Exosomes, Polymeric nanoparticles, Nano-emulsions, Nano-Suspensions, and Hybrid nanocarriers. With a broad scope of this topic, it can prove to be a strong basis to evaluate the current and future prospects based on drug delivery applications using materials that are non-toxic and industrially scalable for imminent applications.
We invite authors to submit Original Research, Reviews, and mini-reviews intended to explore different drug delivery applications to cater to a broader community of researchers/academicians/practitioners working in this scientific domain. Detailed articles on the challenges, limitations, and perspectives are also welcome. We invite research exploring, but not limited to, the following areas:
• Self-assembled nanocarriers for drug delivery applications
• Fabrication of novel combinative nanocarriers composed of biocompatible materials
• Integration of different formulation techniques to develop scalable nanocarrier technology
• Applications of the drug/active molecules loaded nanocarrier in gene, protein, oligonucleotide delivery, and combinative therapy
• Mechanistic detailing and modification of the nanocarriers for the intended use
With an exponential increase in the use of biocompatible materials for the development of novel nanocarriers, the above challenges are anticipated to get corrected. Therefore, a need arises to develop novel drug delivery technologies which could make use of some established nano-based approaches and integrating them with newer ones. They possess a vast potential to provide combinative therapy by employing the use of drugs/active molecules with different solubilities and mechanisms. They can allow for the reduction in the effective dosage of the drugs/active molecules, decreased drug-related side effects, and the provision of sustained/controlled release profiles which can all shorten the duration of therapy for chronic long-term diseases. They can also provide options for a better prognosis/diagnosis of a specific disease, which can further help in designing a better therapeutic regimen. The use of integrative drug delivery approaches can also help to improve the formulation methodology and other attributes, e.g., time and method of preparation, amount of constituents used, use of agitation (temperature, heat, sonication, etc.), and stability in different media.
In recent times, the use of biocompatible excipients or nanocarriers has become thrust in the area of pharmaceutical drug delivery. This research specifically deals with studies showcasing the potential of self-assembly based nanocarriers made up of biocompatible inclusions or modifications. Examples of such nanocarriers and drug delivery technologies include but not limited to- Liposomes, Niosomes, Solid-Lipid nanoparticles, Micelles, Exosomes, Polymeric nanoparticles, Nano-emulsions, Nano-Suspensions, and Hybrid nanocarriers. With a broad scope of this topic, it can prove to be a strong basis to evaluate the current and future prospects based on drug delivery applications using materials that are non-toxic and industrially scalable for imminent applications.
We invite authors to submit Original Research, Reviews, and mini-reviews intended to explore different drug delivery applications to cater to a broader community of researchers/academicians/practitioners working in this scientific domain. Detailed articles on the challenges, limitations, and perspectives are also welcome. We invite research exploring, but not limited to, the following areas:
• Self-assembled nanocarriers for drug delivery applications
• Fabrication of novel combinative nanocarriers composed of biocompatible materials
• Integration of different formulation techniques to develop scalable nanocarrier technology
• Applications of the drug/active molecules loaded nanocarrier in gene, protein, oligonucleotide delivery, and combinative therapy
• Mechanistic detailing and modification of the nanocarriers for the intended use
Keywords: Self-assembly, Biocompatible, Nanocarriers, Combinative Therapy, Vesicular Drug Delivery, Lipid-Based Drug Delivery, Nanoparticles, Nano Drug Delivery, Biomaterials, Biopolymers, Gene Delivery, Oligonucleotide Delivery, Hybrid nanocarriers
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
