About this Research Topic
Bone tissue is a breeding ground for a wide variety of cancer cells, especially breast, prostate, and lung cancer. Adipocytes are metabolically active cells that secrete inflammatory mediators, growth factors and adipokines. They impact the functions and behaviors of neighboring cells and have critical potential in dysregulating normal bone homeostasis. Cancer-associated adipocytes and marrow fat cells are critical for cancer cells to adhere to the bone marrow, including in mediating its effect on cancer progression via the dysregulation of adipokine release and creating a microenvironment suitable for the colonization of bone by cancer cells via the release of many different factors. Marrow fat cells also contribute to the progression of hematopoietic neoplasms. However, the metabolic changes initiated by this complex interaction remain elusive.
The goal of this Research Topic is to present the state-of-the-art in our understanding of the complex interactions between cancer-associated adipocytes or marrow fat cells and metastatic cancer cells in the bone microenvironment, thereby laying a foundation for future research into this intriguing, clinically relevant tissue. Second, more studies should be performed to further uncover whether the diversity and complexity of secreted adipocytokines and marrow fat cells may cause unexpected side-effects and bring about pro-metastasis effects but not the expected anti-metastasis effects. Finally, to identify and validate novel therapeutic targets for skeletal metastases, we focused on the lipid metabolism, marrow adipose tissue, and their molecular signals, which may be pivotal modulators of tumor biology.
We welcome different types of articles including original articles, hypotheses and theory, technology & code articles, as well as reviews and mini-reviews. Within this research frame, submissions are encouraged to focus on the following themes below:
• Basic characteristics of Adipocyte. White and brown adipose tissue, and constitutive and regulated bone marrow adipocytes (cBMA and rBMA).
• Newly image techniques for quantitation of fat content and bone marrow lipids.
• Roles of adipocytes in tumor development and metastasis. This includes adipocytes, lipids, adipocytokines, bone marrow adiposity and cancer, lipid metabolism and lipid transfer in tumor cell survival, adipocytes and mechanisms involved in pre-metastatic niche formation, roles of marrow adipocytes in solid tumor metastasis, and the role of bone marrow adiposity in hematological malignancies.
• Therapeutic Targets: current strategies and future directions for adipokine modulators, marrow adipocytes metabolism inhibitors, and marrow adipocytes inhibitors
The goal of this Research Topic is to present the state-of-the-art in our understanding of the complex interactions between cancer-associated adipocytes or marrow fat cells and metastatic cancer cells in the bone microenvironment, thereby laying a foundation for future research into this intriguing, clinically relevant tissue. Second, more studies should be performed to further uncover whether the diversity and complexity of secreted adipocytokines and marrow fat cells may cause unexpected side-effects and bring about pro-metastasis effects but not the expected anti-metastasis effects. Finally, to identify and validate novel therapeutic targets for skeletal metastases, we focused on the lipid metabolism, marrow adipose tissue, and their molecular signals, which may be pivotal modulators of tumor biology.
We welcome different types of articles including original articles, hypotheses and theory, technology & code articles, as well as reviews and mini-reviews. Within this research frame, submissions are encouraged to focus on the following themes below:
• Basic characteristics of Adipocyte. White and brown adipose tissue, and constitutive and regulated bone marrow adipocytes (cBMA and rBMA).
• Newly image techniques for quantitation of fat content and bone marrow lipids.
• Roles of adipocytes in tumor development and metastasis. This includes adipocytes, lipids, adipocytokines, bone marrow adiposity and cancer, lipid metabolism and lipid transfer in tumor cell survival, adipocytes and mechanisms involved in pre-metastatic niche formation, roles of marrow adipocytes in solid tumor metastasis, and the role of bone marrow adiposity in hematological malignancies.
• Therapeutic Targets: current strategies and future directions for adipokine modulators, marrow adipocytes metabolism inhibitors, and marrow adipocytes inhibitors
Keywords: Adipocyte, Bone marrow, Adipokines, Biomarkers, Bone metastasis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
