About this Research Topic
Another important cellular homeostatic mechanism is autophagy, with important roles in the cellular maintenance, degradation, and secretion. The autophagic process is tightly linked to ROS production since damaged mitochondria are degraded by mitophagy, and modulation of autophagy is a potential mechanism for maintaining mitochondrial fitness and a potential target for cancer therapy.
Targeting redox regulation and autophagy systems or related pathways through biologically active small molecule candidates is considered to be a promising method for cancer therapy. This Research Topic will introduce the currently therapeutic molecules targeting the redox regulation and autophagy systems for cancer therapy, and discuss several challenges in developing cancer therapeutic agents based on ROS or autophagy regulation and propose the direction of future developments.
We welcome Original Research, Review, and Mini-review covering, but not limited to the following subjects:
• Redox-active compounds targeting redox homeostasis or autophagic pathways to induce cell apoptosis, autophagy, DNA damage, and ferroptosis.
• Small molecules capable of modifying ROS levels and potentiating the effect of anticancer drugs.
• Small molecules targeting redox regulation and autophagy, DNA damage systems as drug resistance capable of modifying ROS levels and potentiating the effect of anticancer drugs.
• Redox-active compounds regulating glutathione peroxidase, glutathione, and thioredoxin systems for cancer chemotherapy or chemoprevention.
• Mechanistic study of novel agents that may regulate the ROS homeostasis or induce autophagy for cancer therapy.
• Clinical development and potential of redox-active compounds in cancer therapy.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: Redox regulation;, Reactive oxygen species, Oxidative stress;, Redox-active compounds, Autophagy, Apoptosis, Ferroptosis, Glutathione, Cancer therapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.