Stress Erythropoiesis

Stress erythropoiesis is a distinct pathway triggered by nutrient deficiency, erythropoietic injury and underlying disease that results in increased red cell production when marrow steady state erythropoiesis is insufficient. Differences between stress and steady state erythropoiesis include progenitors, initiating signals and pathways as well as organ systems. Additional differences may occur between species; however, it is known that some stress erythropoiesis-related pathways are highly conserved between mouse and human.

This Red Blood Cell Physiology Research Topic is focused on stress erythropoiesis. Our main goal is to define the underlying mechanisms that generate new erythrocytes during stress erythropoiesis triggered by nutrient deficiency, injury and/or disease-state, discuss in vitro and in vivo experimental models to study human stress erythropoiesis and highlight novel clinical studies focusing on the treatment of stress erythropoiesis.

Topics may include effective and ineffective stress erythropoiesis. Of interest are the molecular mechanisms involved in response to erythropoietic injury, including hemorrhage, hemolysis and marrow ablative chemotherapies. The latter suggests inclusion of hematopoietic stem cell exhaustion as a category of interest. Additional areas of interest include, but are not limited to, stress erythropoiesis secondary to diseases such as sickle cell disease, -thalassemia and myelodysplastic syndrome. We anticipate inclusion of cellular studies, animal models and clinical insights. Original research manuscripts, short communications and reviews will be accepted.