About this Research Topic
Endothelial cells play key roles in organ morphogenesis and physiological function. Well-organized functional angiogenesis is necessary for organ development, regeneration and repair from injury, while deregulated angiogenesis contributes to various pathologies. Spatiotemporal changes in organ-specific chemical and mechanical microenvironment control vascular formation, which is required for organ morphogenesis and homeostasis. Understanding the mechanism by which organ specific microenvironment controls vascular formation will lead to the improvement of tissue repair ability and the development of new strategies for organ regeneration and engineering.
Organ-specific microenvironment controls vascular formation. However, due to the complexity of cellular and non-cellular components in the tissues, it is challenging to delineate the underlying mechanism. To further our understanding of the mechanism of organ specific angiogenesis and vascular functions, we need to employ interdisciplinary technical approaches including organoid systems, organ-on-chip systems, an ex vivo approach, an omics approach, computational modeling, and sophisticated imaging systems. It would be of great interest to characterize dynamic changes in the signaling mechanism and vascular morphology during organ development and regeneration and in pathology using these advanced technologies.
This Research Topic will cover recent advances in biomedical and bioengineering research in the fields of angiogenesis, vascular homeostasis, vascular physiology, microcirculation, and vascular engineering in health and disease. Original Research, Reviews and Mini-Reviews are expected. Areas covered in the Research Topic may include, but are not limited to:
• Organ/tissue specific mechanisms of angiogenesis, lymphangiogenesis and vascular homeostasis in physiology and pathology;
• Novel technology to examine vascular formation and function;
• Effects of mechanical and chemical environment on endothelial differentiation;
• Angiogenesis in organ development, regeneration, and function;
• Advanced vascular engineering techniques;
• Therapeutic strategies for vascular diseases
Organ-specific microenvironment controls vascular formation. However, due to the complexity of cellular and non-cellular components in the tissues, it is challenging to delineate the underlying mechanism. To further our understanding of the mechanism of organ specific angiogenesis and vascular functions, we need to employ interdisciplinary technical approaches including organoid systems, organ-on-chip systems, an ex vivo approach, an omics approach, computational modeling, and sophisticated imaging systems. It would be of great interest to characterize dynamic changes in the signaling mechanism and vascular morphology during organ development and regeneration and in pathology using these advanced technologies.
This Research Topic will cover recent advances in biomedical and bioengineering research in the fields of angiogenesis, vascular homeostasis, vascular physiology, microcirculation, and vascular engineering in health and disease. Original Research, Reviews and Mini-Reviews are expected. Areas covered in the Research Topic may include, but are not limited to:
• Organ/tissue specific mechanisms of angiogenesis, lymphangiogenesis and vascular homeostasis in physiology and pathology;
• Novel technology to examine vascular formation and function;
• Effects of mechanical and chemical environment on endothelial differentiation;
• Angiogenesis in organ development, regeneration, and function;
• Advanced vascular engineering techniques;
• Therapeutic strategies for vascular diseases
Keywords: Angiogenesis, Microcirculation, Vascular Engineering, Stem Cell, Mechanical Force
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
