About this Research Topic
This Research Topic aims to advance the knowledge of lung transplant immunology, specifically the innate immunity and its trained response, adaptive memory response and heterologous immunity, and their roles in primary graft dysfunction (PGD), acute and chronic rejection, to gain new perspectives of lung transplant protection and to develop novel strategies for long-term graft survival.
We welcome submissions of Original Research, Review, Mini Review on the sub-topics below:
1. Primary graft dysfunction (PGD) after lung transplantation
a. Ischemia-reperfusion injury, mitochondria-derived DAMPs, high mobility group box 1 (HMGB1), etc.
b. Neutrophils and/or neutrophil extracellular traps (NETs), DNAs/extracellular histones
c. IL-17 and Inflammation
d. Autophagy
2. Memory of innate cells in lung transplantation
a. Adaptive features of innate immune cells
b. Trained immunity
c. Efferocytosis
d. Macrophage polarization
e. Macrophage subtypes, fibrosis and chronic rejection
3. Adaptive immunity in lung transplantation
a. Th and/or CTL responses to alloantigens
b. Regulatory T cells (Tregs)
c. Antibody-mediated rejection (AMR)
4. Memory T cells in lung transplantation
a. Heterologous immunity
b. CD28- memory T cells
c. Resistance to tolerization
5. Novel approaches for long-term lung transplant survival
a. New preservation solutions and methods
b. Immunologic, metabolic and epigenetic approaches that target trained immunity to modulate immune response
c. Therapeutic strategies of targeting memory T cells to alter their properties
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.