About this Research Topic
Foodborne parasitic infections are a worldwide problem. Twenty-four foodborne parasites (FBP) have been listed in the global risk ranking by FAO/WHO. Although the number has been narrowed down from an initial list of 93, the foodborne parasites are still of global concern due to their huge impacts on public health and economic activities.
The interaction between FBP and host is necessary for the FBP invasion and evolution, but largely lacking a mechanistic explanation. Several FBP such as Microsporidia, Toxoplasma gondii, Trypanosoma cruzi, Cryptosporidium, Giardia and Entamoeba histolytica are orally transmitted parasites. At the early stage of infection, they will adapt for persistence in hostile environments after being ingested into the host and utilize multiple strategies to overcome and even exploit innate immune responses to facilitate their invasion. For instance, some parasites could release serpins which could inhibit the function of the host’s serine proteases and protect themselves from the host immune attacking. The parasite infection in the host cells will be also dependent on the interaction of a specific receptor ligand which leads to the internalization of the parasite into host cells (e.g. parasitophorous vacuole). Understanding the interaction mechanism of FBP with their host could pave the way for future investigative strategies and the ultimate identification of new drug and vaccine targets.
A deep understanding of cellular and molecular mechanisms underlying the pathogenicity of harmful foodborne parasites as well as host response may help to develop alternative and effective intervention strategies in foodborne parasite control. This Research Topic aims to focus on the mechanisms of foodborne parasite and host interaction and understanding multiple strategies developed by foodborne parasites to facilitate their adaptation and successful survival in the host. Roles of novel parasite proteins or factors in host immune response and parasite-host interactions are also included.
The manuscripts describing the novel knowledge of the interaction of infection related to parasites proteins with host cell receptors or any information to complement the gaps in host-parasite interactions will be welcomed. We welcome Original Research and Review articles addressing but not limited to the following aspects:
• Advances in the study of coevolution between FBP and their hosts;
• Impact of FBP-host interaction on the parasite virulence and transmission;
• The early mechanisms and events occurring in FBP infection;
• The interaction mechanism of FBP with host innate immune system during the cell invasion.
The interaction between FBP and host is necessary for the FBP invasion and evolution, but largely lacking a mechanistic explanation. Several FBP such as Microsporidia, Toxoplasma gondii, Trypanosoma cruzi, Cryptosporidium, Giardia and Entamoeba histolytica are orally transmitted parasites. At the early stage of infection, they will adapt for persistence in hostile environments after being ingested into the host and utilize multiple strategies to overcome and even exploit innate immune responses to facilitate their invasion. For instance, some parasites could release serpins which could inhibit the function of the host’s serine proteases and protect themselves from the host immune attacking. The parasite infection in the host cells will be also dependent on the interaction of a specific receptor ligand which leads to the internalization of the parasite into host cells (e.g. parasitophorous vacuole). Understanding the interaction mechanism of FBP with their host could pave the way for future investigative strategies and the ultimate identification of new drug and vaccine targets.
A deep understanding of cellular and molecular mechanisms underlying the pathogenicity of harmful foodborne parasites as well as host response may help to develop alternative and effective intervention strategies in foodborne parasite control. This Research Topic aims to focus on the mechanisms of foodborne parasite and host interaction and understanding multiple strategies developed by foodborne parasites to facilitate their adaptation and successful survival in the host. Roles of novel parasite proteins or factors in host immune response and parasite-host interactions are also included.
The manuscripts describing the novel knowledge of the interaction of infection related to parasites proteins with host cell receptors or any information to complement the gaps in host-parasite interactions will be welcomed. We welcome Original Research and Review articles addressing but not limited to the following aspects:
• Advances in the study of coevolution between FBP and their hosts;
• Impact of FBP-host interaction on the parasite virulence and transmission;
• The early mechanisms and events occurring in FBP infection;
• The interaction mechanism of FBP with host innate immune system during the cell invasion.
Keywords: Foodborne parasite; Interaction; Pathogenesis; Immunity; Treatment
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
