Chemical Allergy and The Relevance of New Models

Chemical allergy represents an adverse health effect that results from an immune response activation following chemical exposure. Among the different forms of chemical allergies, the two most relevant for occupational toxicology are skin sensitization (resulting in allergic contact dermatitis) and sensitization of the respiratory tract associated with occupational rhinitis and asthma. Chemical allergens are low molecular weight molecules able to activate the immune system. To stimulate an immune response, chemical allergens function as haptens binding to carrier proteins. Several molecules can be involved in chemical allergy such as micro and nano-plastics, particles, pesticides, endocrine disruptors, drugs, fragrances, among others. The initiation and development of chemical allergy phenomena are of considerable interest and importance also for the toxicologist, who has the responsibility of identifying and characterizing the allergenic potential of chemicals and estimating the risk they pose to human health.

The main goal of this Research Topic is to combine interdisciplinary evidence on chemical allergy, covering the biological, pharmaceutical, toxicological, and clinical points of view. The purpose is to evaluate experimental evidence supporting the contribution of these interactions in chemical allergy. Contributions that consider alternative approaches to animal use, interdisciplinary approaches, and mechanistic studies will be considered with much interest. Additionally, risk assessment considerations and approaches are strongly supported.

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