About this Research Topic
Extracellular vesicles (EVs) are sub-cellular structures released by most eukaryotic cell types. They can mediate the exchange of a broad array of molecules between adjacent or distant cells by transferring their cargo (proteins, RNAs, lipids and carbohydrates), along with membrane receptors and antigen presentation complexes. Thus, they have emerged as important mediators of intercellular communication.
Over the past years, the critical role of EVs in hemostasis and thrombosis has been recognized. EVs can support or directly promote coagulation and modulate the pro-coagulatory phenotype of vascular cells. Therefore, EVs are considered as promising biomarkers and therapeutic targets for management of thrombotic risk.
The aim of this Research Topic is to collate a comprehensive collection of articles related to the involvement of EVs in thrombotic disorders. Specifically, articles should address the impact of EVs of vascular or tumor cell origin as well as EVs originating from damaged tissues and organs in the pathogenesis of arterial and venous thrombosis, vascular inflammation, pulmonary embolism, disseminated intravascular coagulation as well as in immuno-thrombosis associated with sepsis or severe COVID-19.
In particular, the mechanisms by which EVs influence pathological vascular processes and eventual changes in their cargo, as well as alterations of the repertoire of their surface molecules or membrane rearrangements that support these mechanisms should be addressed.
We welcome the submission of Original Research Articles, Reviews and Mini-Reviews, including the following topics:
• Role of EVs in aberrant coagulation in pathological conditions, such as viral and bacterial infection, cancer, liver failure, trauma and cardiovascular disease;
• EVs contained in blood products and potential implications related to the transfusion of blood products;
• Effects of EVs on the endothelium and vascular cells;
• Methodological aspects of characterizing the pro-coagulant effect of EVs as well as links between their phospholipid composition or surface molecules, and their pro-coagulant potential;
• Mechanisms counter-acting the pro-coagulant role of EVs;
• EVs as biomarkers and therapeutic targets/tools in management of thrombotic risk.
Over the past years, the critical role of EVs in hemostasis and thrombosis has been recognized. EVs can support or directly promote coagulation and modulate the pro-coagulatory phenotype of vascular cells. Therefore, EVs are considered as promising biomarkers and therapeutic targets for management of thrombotic risk.
The aim of this Research Topic is to collate a comprehensive collection of articles related to the involvement of EVs in thrombotic disorders. Specifically, articles should address the impact of EVs of vascular or tumor cell origin as well as EVs originating from damaged tissues and organs in the pathogenesis of arterial and venous thrombosis, vascular inflammation, pulmonary embolism, disseminated intravascular coagulation as well as in immuno-thrombosis associated with sepsis or severe COVID-19.
In particular, the mechanisms by which EVs influence pathological vascular processes and eventual changes in their cargo, as well as alterations of the repertoire of their surface molecules or membrane rearrangements that support these mechanisms should be addressed.
We welcome the submission of Original Research Articles, Reviews and Mini-Reviews, including the following topics:
• Role of EVs in aberrant coagulation in pathological conditions, such as viral and bacterial infection, cancer, liver failure, trauma and cardiovascular disease;
• EVs contained in blood products and potential implications related to the transfusion of blood products;
• Effects of EVs on the endothelium and vascular cells;
• Methodological aspects of characterizing the pro-coagulant effect of EVs as well as links between their phospholipid composition or surface molecules, and their pro-coagulant potential;
• Mechanisms counter-acting the pro-coagulant role of EVs;
• EVs as biomarkers and therapeutic targets/tools in management of thrombotic risk.
Keywords: Thrombosis, Extracellular Vesicles, Coagulation, Hemostasis, Thrombotic Disorders, Vascular Inflammation, Pulmonary Embolism
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
