About this Research Topic
The mammalian testis is a multifunctional organ uniquely designed for gamete formation (the spermatozoan) and homeostatic regulation of reproduction. A precisely orchestrated interplay of hormonal and cell biological features is necessary to successfully produce the male gamete and utilize it effectively in successful completion of its function.
We propose a collection of original research articles focusing on this interplay of cellular components and extrinsic regulators to update present knowledge focusing on the dynamic aspects engaging hormonal regulation of testis form and function.
The editors propose a bottom up organization of papers extending from the stem cell and its niche to the functional spermatozoa. Topics in some semblance of order will include:
1. Hypothalamic-pituitary axis; FSH synthesis, GnRH signaling
2. Stem cell function and regulation in the testis
3. Hormonal regulation of spermatogenesis
4. New molecular technologies for the regulation of spermatogenesis
5. Use of new methodologies for single cell analysis of genome integrity and function
6. Use of new methodologies for in vivo and in vitro analysis of genome integrity, chromatin function and non-genomic signaling
7. Leydig cell formation, transcription, and steroidogenic function: effects on spermatogenesis
8. Use of new molecular technologies for the regulation of spermatogenesis
9. Paracrine signaling in the testis in the regulation of spermatogenesis
10. Endocrine disruptor effects on endocrine function and spermatogenesis
11. Testosterone and disease
12. Aging, oxidative stress and spermatogenesis
13. Epididymis and sperm maturation
14.New approaches to male contraception
We propose a collection of original research articles focusing on this interplay of cellular components and extrinsic regulators to update present knowledge focusing on the dynamic aspects engaging hormonal regulation of testis form and function.
The editors propose a bottom up organization of papers extending from the stem cell and its niche to the functional spermatozoa. Topics in some semblance of order will include:
1. Hypothalamic-pituitary axis; FSH synthesis, GnRH signaling
2. Stem cell function and regulation in the testis
3. Hormonal regulation of spermatogenesis
4. New molecular technologies for the regulation of spermatogenesis
5. Use of new methodologies for single cell analysis of genome integrity and function
6. Use of new methodologies for in vivo and in vitro analysis of genome integrity, chromatin function and non-genomic signaling
7. Leydig cell formation, transcription, and steroidogenic function: effects on spermatogenesis
8. Use of new molecular technologies for the regulation of spermatogenesis
9. Paracrine signaling in the testis in the regulation of spermatogenesis
10. Endocrine disruptor effects on endocrine function and spermatogenesis
11. Testosterone and disease
12. Aging, oxidative stress and spermatogenesis
13. Epididymis and sperm maturation
14.New approaches to male contraception
Keywords: Spermatogenesis, testis, hormonal regulation, hypothalamic-pituitary axis, spermatozoa, testosterone, chromatin, FSH synthesis, GnRH signaling
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