About this Research Topic
The bone marrow system is responsible for skeletal development and bone remodeling throughout life, thanks to the finely regulated activity of the bone-resorbing osteoclasts and the bone-forming osteoblasts. To maintain bone homeostasis, bone-residing cells establish dynamic cross-communications between the bone and the mesenchymal-stromal, hematopoietic, endothelial, muscle, immune and neural systems.
Dysregulation in this crosstalk and in the bone microenvironment leads to alterations in bone development and quality, resulting in the onset of pathologies including osteoporosis, osteoarthritis, osteomalacia, bone-homing tumors and fractures but also alterations in hematopoiesis, immune or neuronal responses or vascularization.
In the recent years, the central role of osteoclasts in this crosstalk has been emphasized by in-depth analysis of the mechanisms regulating their formation and activity as well as their communication with their environment. Therefore, osteoclasts appear as key targets for the development of novel pharmacological or cellular approaches for the diagnosis and therapy for pathologies related to bone destruction and beyond.
This Research Topic is devoted to provide a profound comprehension of the regulatory mechanisms involved in the function and differentiation of osteoclasts, in their interaction with the bone marrow environment, as well as their implication in diseases. It will also cover the potential of osteoclasts as cellular targets for the prevention and/or treatment of bone pathologies. A better understanding of the relevant molecular mechanisms governing osteoclast activation and function by surrounding cells and systems could pave the way for the development of novel therapeutic strategies.
We welcome contributions of different types of articles including original research articles, hypotheses and theory, as well as reviews and mini reviews on osteoclast pathophysiology, in particular the following
themes:
• Implication of osteoclasts in pathological conditions including rare diseases, chronic rheumatic diseases, cancer, infection, osteoporosis;
• Perspectives in pharmacological targeting of osteoclasts for diagnosis and treatment of bone pathologies;
• Membrane receptors and cell signaling in osteoclast physiology and dysfunctions;
• The role of metabolism in osteoclast physiopathology;
• Osteoclast differentiation, fusion and function;
• Osteoclast plasticity and interaction with bone marrow cells, including osteoimmunology;
• The role of circulome (extracellular vesicles, nanotunnels, microRNAs, long non-coding RNAs, etc) in osteoclast development and activity.
Dysregulation in this crosstalk and in the bone microenvironment leads to alterations in bone development and quality, resulting in the onset of pathologies including osteoporosis, osteoarthritis, osteomalacia, bone-homing tumors and fractures but also alterations in hematopoiesis, immune or neuronal responses or vascularization.
In the recent years, the central role of osteoclasts in this crosstalk has been emphasized by in-depth analysis of the mechanisms regulating their formation and activity as well as their communication with their environment. Therefore, osteoclasts appear as key targets for the development of novel pharmacological or cellular approaches for the diagnosis and therapy for pathologies related to bone destruction and beyond.
This Research Topic is devoted to provide a profound comprehension of the regulatory mechanisms involved in the function and differentiation of osteoclasts, in their interaction with the bone marrow environment, as well as their implication in diseases. It will also cover the potential of osteoclasts as cellular targets for the prevention and/or treatment of bone pathologies. A better understanding of the relevant molecular mechanisms governing osteoclast activation and function by surrounding cells and systems could pave the way for the development of novel therapeutic strategies.
We welcome contributions of different types of articles including original research articles, hypotheses and theory, as well as reviews and mini reviews on osteoclast pathophysiology, in particular the following
themes:
• Implication of osteoclasts in pathological conditions including rare diseases, chronic rheumatic diseases, cancer, infection, osteoporosis;
• Perspectives in pharmacological targeting of osteoclasts for diagnosis and treatment of bone pathologies;
• Membrane receptors and cell signaling in osteoclast physiology and dysfunctions;
• The role of metabolism in osteoclast physiopathology;
• Osteoclast differentiation, fusion and function;
• Osteoclast plasticity and interaction with bone marrow cells, including osteoimmunology;
• The role of circulome (extracellular vesicles, nanotunnels, microRNAs, long non-coding RNAs, etc) in osteoclast development and activity.
Keywords: Osteoimmunology, bone pathologies, cell metabolism, circulome, bone marrow environment.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
