About this Research Topic
This Research Topic is part of the Model Organisms in Aging Research series. Other titles in this series are:
• Model Organisms in Aging Research:Drosophila melanogaster
• Model Organisms in Aging Research: Rodent Models
Background
The discovery of longevity pathways in invertebrate model organisms has been pivotal for the explosion of research in the aging field. Model organisms are amenable to both genetic manipulation and environmental interventions that extend lifespan, slow down the appearance of aging biomarkers and rejuvenate tissues. The simplicity of invertebrates allows the development of concepts and technologies that can then be applied to more complex organisms, including humans.
Goal
Successful strategies developed in Caenorhabditis Elegans (C. elegans) include in vivo tools to study diverse aspects of aging research, such as cross-tissue regulation of longevity signalling pathways and host-microbiota interactions and their impact on molecular dysfunction. These tools have led to key insights into the non-linear relationship between metabolism, proteostasis, and aging processes. Furthermore, in silico tools are being developed at a fast pace advancing the prospects of predictive medicine. The goal of this Research Topic is to publish research in any of these areas applied to C. elegans.
Scope and information for Authors
Manuscripts submitted to this Research Topic should include or consider the role of C. elegans. for aging research. The scope of this Research Topic covers, but is not limited to, the following themes and questions:
• How longevity pathways prevent molecular dysfunction
• How molecular dysfunction drives aging of tissues and organisms
• New technologies to advance aging research using insights from C.elegans
• New advances in the biology of mitochondria and metabolism including research into host-microbiota interactions
• New advances related to systems physiology and integrative cross-tissue interactions
• The advantages or disadvantages of using C.elegans in aging research
• Model Organisms in Aging Research:Drosophila melanogaster
• Model Organisms in Aging Research: Rodent Models
Background
The discovery of longevity pathways in invertebrate model organisms has been pivotal for the explosion of research in the aging field. Model organisms are amenable to both genetic manipulation and environmental interventions that extend lifespan, slow down the appearance of aging biomarkers and rejuvenate tissues. The simplicity of invertebrates allows the development of concepts and technologies that can then be applied to more complex organisms, including humans.
Goal
Successful strategies developed in Caenorhabditis Elegans (C. elegans) include in vivo tools to study diverse aspects of aging research, such as cross-tissue regulation of longevity signalling pathways and host-microbiota interactions and their impact on molecular dysfunction. These tools have led to key insights into the non-linear relationship between metabolism, proteostasis, and aging processes. Furthermore, in silico tools are being developed at a fast pace advancing the prospects of predictive medicine. The goal of this Research Topic is to publish research in any of these areas applied to C. elegans.
Scope and information for Authors
Manuscripts submitted to this Research Topic should include or consider the role of C. elegans. for aging research. The scope of this Research Topic covers, but is not limited to, the following themes and questions:
• How longevity pathways prevent molecular dysfunction
• How molecular dysfunction drives aging of tissues and organisms
• New technologies to advance aging research using insights from C.elegans
• New advances in the biology of mitochondria and metabolism including research into host-microbiota interactions
• New advances related to systems physiology and integrative cross-tissue interactions
• The advantages or disadvantages of using C.elegans in aging research
Keywords: Model Organisms, Longevity, Caenorhabditis Elegans, aging, Interactions
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
