About this Research Topic
Since December 2019, the infectious illness caused by the “severe acute respiratory syndrome coronavirus 2” (SARS-CoV-2), called “coronavirus disease-19” (COVID-19), has rapidly spread throughout the world becoming a pandemic emergency. In addition to common systemic manifestations such as fever and pneumonia, COVID-19 has been documented to be associated with different extra-pulmonary signs, including skin manifestations. Although the pathophysiological basis of COVID-19-associated skin lesions is still largely unknown and the role of SARS-CoV-2 in their pathogenesis is still debated, it may be postulated that the direct hematogenous spread of the virus in the skin may be responsible for certain clinical patterns, while the hyper-inflammatory response secondary to the systemic infection may lead to other skin phenotypes. Moreover, as COVID-19 vaccine administration increases, recognition and understanding of novel vaccine-related skin reactions are essential.
The aim of this Research Topic is to gather a collection of basic Review articles and Original Research articles on COVID-19-associated skin manifestations and COVID-19 vaccine-related cutaneous reactions in order to (i) provide an update on epidemiological and clinical features of these conditions; (ii) promote improved understanding of their physiopathological basis; (iii) identify possible correlations between the extent of skin manifestations and COVID-19 severity, and (iv) pave the way to a pathogenesis-driven therapeutic approach.
In this Research Topic, we welcome the submission of Reviews, Mini-Revies, Original Research Articles, Case Series, and Case Reports that cover the following topics on COVID-19-associated skin manifestations and COVID-19 vaccine-related cutaneous reactions:
• Genetics
• Role of immune cells and cytokines
• Autoinflammation and COVID-19-associated skin manifestations
• Urticarial rash
• Confluent erythematous-maculopapular-morbilliform rash
• Papulovesicular exanthem
• Chilblain-like acral pattern
• Livedo reticularis-livedo racemosa-like pattern
• Purpuric 'vasculitic' pattern
• Multisystem inflammatory syndrome in children (MIS-C)
• Telogen effluvium
• COVID-19 vaccine-related skin reactions
• New therapeutic approaches
The aim of this Research Topic is to gather a collection of basic Review articles and Original Research articles on COVID-19-associated skin manifestations and COVID-19 vaccine-related cutaneous reactions in order to (i) provide an update on epidemiological and clinical features of these conditions; (ii) promote improved understanding of their physiopathological basis; (iii) identify possible correlations between the extent of skin manifestations and COVID-19 severity, and (iv) pave the way to a pathogenesis-driven therapeutic approach.
In this Research Topic, we welcome the submission of Reviews, Mini-Revies, Original Research Articles, Case Series, and Case Reports that cover the following topics on COVID-19-associated skin manifestations and COVID-19 vaccine-related cutaneous reactions:
• Genetics
• Role of immune cells and cytokines
• Autoinflammation and COVID-19-associated skin manifestations
• Urticarial rash
• Confluent erythematous-maculopapular-morbilliform rash
• Papulovesicular exanthem
• Chilblain-like acral pattern
• Livedo reticularis-livedo racemosa-like pattern
• Purpuric 'vasculitic' pattern
• Multisystem inflammatory syndrome in children (MIS-C)
• Telogen effluvium
• COVID-19 vaccine-related skin reactions
• New therapeutic approaches
Keywords: COVID-19, SARS-CoV-2, vaccine, exanthem, skin, cutaneous adverse reactions, MIS-C
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
