About this Research Topic
Biofilms are the group of adherent microbial communities that remain attached to one another, with the biotic or abiotic surfaces by self-secreted extracellular polymeric matrix. Multicellular biofilm communities are found in most of the biotic and abiotic habitats including in the human body. Biofilms provide a protective shell for microorganisms and are found to be associated with 60-80% of infections. The formation of biofilm is a key virulence factor for various types of species that are involved in chronic infections and evasion of various host immune responses. Dissemination of various genetic factors associated with microbial virulence and consequent development of resistance is accomplished by the biofilm. The multifactorial nature of the biofilm is responsible for the development of tolerance against antimicrobial drugs and has resulted in the increase of great challenge in the use of conventional antimicrobial chemotherapy. It is the need of an hour to explore additional studies orienting towards the interactions existing between various species within the biofilm that thereby affects the nature, survival and development of the sessile communities within the biofilm.
This Research Topic is intended to collect original updates on the role of biofilms causing dysbiosis and diseases, and the novel strategies in microbiological diagnosis, antimicrobial susceptibility studies and possible treatments of biofilm-related infections. The structural architecture of multispecies consortium dependent on the extracellular polymeric matrix that remains metabolically active, thus helping the functional integration of the consortia will be elucidated. The different types of organic compounds, waste products, electron acceptors, autoinducers, and other substances that help in the development of biofilm and a contemporary challenge in the field: to understand how Quorum Sensing (QS) works in the host environment will also be a focus.
This research topic focuses on studies that investigate and discuss:
• New and challenging Biofilm formation related issues in acute and chronic infections
• Genomic and Metabolomic study of Biofilm forming natural microbiota of humans
• Metabolome analysis for host- microbiota interactions, and Novel approaches in metabolomics analysis of biofilm
• Role of quorum sensing and its importance in imparting virulence
• Immune responses against biofilm, and immune evasions and antibiotic resistance by biofilm
• Novel anti-biofilm drugs and treatments, mechanism of actions, and Reprogramming of metabolomics of biofilms
This Research Topic is intended to collect original updates on the role of biofilms causing dysbiosis and diseases, and the novel strategies in microbiological diagnosis, antimicrobial susceptibility studies and possible treatments of biofilm-related infections. The structural architecture of multispecies consortium dependent on the extracellular polymeric matrix that remains metabolically active, thus helping the functional integration of the consortia will be elucidated. The different types of organic compounds, waste products, electron acceptors, autoinducers, and other substances that help in the development of biofilm and a contemporary challenge in the field: to understand how Quorum Sensing (QS) works in the host environment will also be a focus.
This research topic focuses on studies that investigate and discuss:
• New and challenging Biofilm formation related issues in acute and chronic infections
• Genomic and Metabolomic study of Biofilm forming natural microbiota of humans
• Metabolome analysis for host- microbiota interactions, and Novel approaches in metabolomics analysis of biofilm
• Role of quorum sensing and its importance in imparting virulence
• Immune responses against biofilm, and immune evasions and antibiotic resistance by biofilm
• Novel anti-biofilm drugs and treatments, mechanism of actions, and Reprogramming of metabolomics of biofilms
Keywords: Biofilms, Extracellular polymeric matrix, dysbiosis, Beneficial multi species biofilms, Quorum Sensing, Antimicrobial resistance, Novel anti-biofilm drugs and treatments
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