Metabolism in pathophysiology

The spreading of unhealthy lifestyle and bad dietary habits is increasing the prevalence of metabolic-related pathologies worldwide. Key triggers such as inadequate nutrition or the exposure to toxic compounds lead to pathologies such as metabolic syndrome, gastrointestinal disorders and even increase the risk of cancer development. Metabolic syndrome is estimated to affect 38% of the global population and implies around 20% of healthcare expenditures in developed countries. Added to aging, patients with metabolic disorders are more prone to develop cardiovascular diseases, representing around 31% of deaths worldwide. Among gastrointestinal disorders, liver pathologies are also increasing their prevalence, with non-alcoholic fatty liver disease (NAFLD) affecting around 25% of the global population. In cancer the metabolic shifting has been widely characterized as a hallmark that gives tumor cells a competitive advantage.

Considering the so-elevated prevalence of metabolic-associated pathologies, as well as their increasing risk of developing prevalent diseases such as cardiovascular diseases or cancer, this Research Topic aims to highlight them in order to increase awareness. Although certain metabolic-associated pathologies may be solved by a change in lifestyle and nutrition, sometimes the long-term compliance of the patient is difficult. Added to this, in certain cases the disease reaches states where therapies are mandatory for its reversion. The understanding of the underlying metabolism is mandatory in order not to improve these conditions but also to prevent their development.

We encourage the submission of scientific contributions focused on metabolic dysregulation and their consequences in the development of cardiovascular diseases, gastrointestinal disorders, metabolic syndrome or cancer. Although Original Research articles are preferable for submission, contributions in the form of Review articles are also welcome.