Oxidative Stress in Cell Death and Human Disease: Molecular Mechanisms and Translational Research

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Background

Reactive oxygen species (ROS) react preferentially with certain atoms to regulate functions ranging from cell homeostasis to cell death. Oxidative stress, initiated by high levels of ROS, has been confirmed to be associated with various human pathologies, including aging, carcinogenesis and degenerative disorders. In the last years, numerous studies have discovered that oxidative stress participates in the pathogenesis of human disease by promoting the cell death process, including the well-defined apoptosis and newly discovered necroptosis, pyroptosis, ferroptosis, as well as oxeiptosis, or by disrupting the pro-survival signals such as autophagy and unfolded protein response. Thus, reducing oxidative stress to maintain the balance between cell death and cell survival is of particular importance in the treatment of human diseases. However, the critical role and detailed mechanisms of oxidative stress in cell death and human disease, as well as the translational potential of this information into medical advances still need to be studied.

This Research Topic aims to collate original research articles as well as review articles that will contribute to broaden the understanding of the cellular and molecular mechanisms regulated by oxidative stress during cell death and human diseases. We welcome all articles that describe new and essential targets and mechanisms regulated by oxidative stress that could be exploited for translational research in human diseases.

Potential topics include but are not limited to the following:
• New molecular mechanisms of oxidative stress in cell death including apoptosis, necroptosis, pyroptosis, ferroptosis ,and oxeiptosis
• Cellular protective signaling pathways that contribute to cellular repair during oxidative stress and the potential interplay between these pathways
• New cellular mechanisms of oxidative stress in human diseases including aging, carcinogenesis and degenerative disorders
• New strategies to prevent or treat cellular damage and human disease under oxidative stress
• Translational research for the treatment or prevention of human aging, carcinogenesis and degenerative diseases initiated and developed by oxidative stress

Keywords: cell homeostasis, apoptosis, necroptosis, pyroptosis, ferroptosis, oxeiptosis, aging, autophagy, unfolded protein response, degenerative disease

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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