About this Research Topic
Peripheral nerve injury is a common condition, causing a wide range of effects, including loss of motor function, sensory function, or both. It results in a poor quality of life and the loss of a substantial amount of social laborers. Also, it has caused a significant economic burden on individuals, their families, and our society. Comparing to the central nervous system, the peripheral nervous system (PNS) presents a better reparative and regenerative capacity, however, it still cannot reach full recovery after injury. Therefore, more clinical and basic research are required to improve the treatment outcome of peripheral nerve injury. In recent years, many studies have been focused on understanding the process of PNS repair and reconstruction after injury and aim to find novel clinical therapeutical methods.
Schwann cells and Schwann-like cells derived from stem cells have been shown to play important roles in PNS. The advancement of genomics, epigenomics and proteomics research methods has made it possible to study the regulation of transcription, post-transcriptional modification and translation in Schwann cells and Schwann-like cells derived from stem cells, as well as the biological roles of these cells in PNS regulation, but many cellular and molecular mechanisms are still unclear and need to be farther investigated.
This Research Topic aims to investigate the regulatory role of Schwann Cells and Schwann-like cells derived from stem cells in PNS development, aging, injury, repair and regeneration.
We welcome all the Original Research Articles and Reviews focus on, but not limited to, the following topic:
-Exploring the epigenetic regulation mechanism of Schwann Cells and Schwann-like cells derived from stem cells in PNS.
-Finding the difference of Schwann Cells in the various types of nerve fibers, such as motor nerves, sensory nerves and autonomic nerves.
-Exploring the regulatory roles of Schwann Cells in PNS under pathological conditions, such as diabetes, Grave disease, tumor, etc.
-Investigating morphologic and functional changes of Schwann Cells during PNS aging.
-Finding possibility to construct Genetic Engineering Schwann Cells, such as new tissue engineering nerve graft to promote peripheral nerve regeneration.
-Discovering novel therapeutical approach to improving the PNS repair capability after injury.
Schwann cells and Schwann-like cells derived from stem cells have been shown to play important roles in PNS. The advancement of genomics, epigenomics and proteomics research methods has made it possible to study the regulation of transcription, post-transcriptional modification and translation in Schwann cells and Schwann-like cells derived from stem cells, as well as the biological roles of these cells in PNS regulation, but many cellular and molecular mechanisms are still unclear and need to be farther investigated.
This Research Topic aims to investigate the regulatory role of Schwann Cells and Schwann-like cells derived from stem cells in PNS development, aging, injury, repair and regeneration.
We welcome all the Original Research Articles and Reviews focus on, but not limited to, the following topic:
-Exploring the epigenetic regulation mechanism of Schwann Cells and Schwann-like cells derived from stem cells in PNS.
-Finding the difference of Schwann Cells in the various types of nerve fibers, such as motor nerves, sensory nerves and autonomic nerves.
-Exploring the regulatory roles of Schwann Cells in PNS under pathological conditions, such as diabetes, Grave disease, tumor, etc.
-Investigating morphologic and functional changes of Schwann Cells during PNS aging.
-Finding possibility to construct Genetic Engineering Schwann Cells, such as new tissue engineering nerve graft to promote peripheral nerve regeneration.
-Discovering novel therapeutical approach to improving the PNS repair capability after injury.
Keywords: Schwann Cells, Peripheral Nervous System, Schwann-like cells, Stem Cell, Aging, Development, Regeneration
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
