About this Research Topic
Gastrointestinal malignancies encompass a large number of tumor types, and collectively are responsible for a significant portion of new cancer cases annually. According to the IARC database, colorectal cancer alone is responsible for approximately 10% of new cases of cancer worldwide annually. There is significant heterogeneity across the various tumor types, with different pathways and factors involved in oncogenesis, as well as varying degrees of prognosis depending on the tumor type.
Non-coding RNAs (ncRNAs) contribute to a significant portion of the human transcriptome, and of particular interest are the micro-RNAs (miRNAs), long ncRNAs (lncRNAs), and circular ncRNAs (circRNAs). With the advent of next-generation sequencing and new technologies such a minimally invasive biopsy techniques, there is a growing body of evidence elucidating the role of ncRNAs in the progression of various form of gastrointestinal cancers. Furthermore, in addition to their relevance to cancer progression, these ncRNAs have important potential as biomarkers and prognostic markers for various GI cancers.
This Research Topic aims to provide insight into the role of ncRNAs in GI cancers in, but not limited to, the following areas:
• ncRNAs as prognostic and diagnostic markers
• ncRNAs role in tumor progression
• ncRNAs as predictors for drug response
• Novel technologies related to studying ncRNAs
• Precision medicine involving ncRNAs
Please note: The findings based on omics data integration should be also supported by observational/experimental data. Descriptive studies and studies consisting only of bioinformatic investigation of accessible genomic or transcriptomic data do not fall within the scope of the journal.
Non-coding RNAs (ncRNAs) contribute to a significant portion of the human transcriptome, and of particular interest are the micro-RNAs (miRNAs), long ncRNAs (lncRNAs), and circular ncRNAs (circRNAs). With the advent of next-generation sequencing and new technologies such a minimally invasive biopsy techniques, there is a growing body of evidence elucidating the role of ncRNAs in the progression of various form of gastrointestinal cancers. Furthermore, in addition to their relevance to cancer progression, these ncRNAs have important potential as biomarkers and prognostic markers for various GI cancers.
This Research Topic aims to provide insight into the role of ncRNAs in GI cancers in, but not limited to, the following areas:
• ncRNAs as prognostic and diagnostic markers
• ncRNAs role in tumor progression
• ncRNAs as predictors for drug response
• Novel technologies related to studying ncRNAs
• Precision medicine involving ncRNAs
Please note: The findings based on omics data integration should be also supported by observational/experimental data. Descriptive studies and studies consisting only of bioinformatic investigation of accessible genomic or transcriptomic data do not fall within the scope of the journal.
Keywords: ncRNAs, gastrointestinal cancers, miRNAs, lncRNAs, circRNA
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
