About this Research Topic
A massive class of macromolecules, lipids are essential to cellular function through a variety of biological, structural, and mechanical roles. The variation in cellular lipids allows for the fluid structure of the plasma membrane, the formation of cell signaling mediators, and the regulation of key cellular processes. As such, the regulation and storage of cellular lipids is a tightly controlled process and is influenced by genetic factors as well as diet, aging, exercise, and other environmental cues. A large body of evidence spanning diverse fields indicates that cellular lipids take part in in the response to mechanical stimuli, prompting a discussion of lipids in mechanobiology to be further explored. Whether it be lipid derivatives produced in the response to shear force or the influence of mechanical stress on lipid metabolism, lipids are now recognized to play key roles in response to mechanical stimuli to maintain homeostasis in many cell types.
The goal of Lipids in Mechanobiology is to provide a concerted forum focused on the multifaceted roles of any variety of lipids in mechanosensation and mechanotransduction of biophysical forces, as well as the impact of mechanical stressors on lipid signaling and metabolism in health and disease. We aim to highlight both seminal and recent advances in this field with a special emphasis on cardiovascular pathophysiology, with discussions ranging from how lipids take part in active mechanotransduction to how pathological mechanical stress alters lipid metabolism. Therefore, we ultimately aim to generate a diverse yet focused view into the many mechanisms in which cellular lipids respond to, and are impacted by, the perpetual biophysical forces present in nature.
Lipids in Mechanobiology requests submissions detailing the roles of lipids in mechanosensation and mechanotransduction of biophysical forces. The impact of various mechanical stressors on the lipid milieu, plasma membrane structure of cells and organelles, lipid metabolism, and the production of lipid derivatives as cell signaling mediators are desired topics. Submissions directly related to cardiovascular physiology in health and disease are preferred but topics detailing the influence of mechanical stimuli on cellular lipids in any context will be considered. Articles describing protein-lipid interactions that play a role in mechanobiology are highly encouraged. Reviews should be mindful of methodological approaches used across fields and should include a critical analysis of findings and conclusions from studies discussed. Original work is welcome so long as it advances our understanding of how lipids respond to and are impacted by biophysical forces. In addition, we welcome timely articles relevant to atherosclerosis and methodology aimed at investigating lipids in health and disease.
The goal of Lipids in Mechanobiology is to provide a concerted forum focused on the multifaceted roles of any variety of lipids in mechanosensation and mechanotransduction of biophysical forces, as well as the impact of mechanical stressors on lipid signaling and metabolism in health and disease. We aim to highlight both seminal and recent advances in this field with a special emphasis on cardiovascular pathophysiology, with discussions ranging from how lipids take part in active mechanotransduction to how pathological mechanical stress alters lipid metabolism. Therefore, we ultimately aim to generate a diverse yet focused view into the many mechanisms in which cellular lipids respond to, and are impacted by, the perpetual biophysical forces present in nature.
Lipids in Mechanobiology requests submissions detailing the roles of lipids in mechanosensation and mechanotransduction of biophysical forces. The impact of various mechanical stressors on the lipid milieu, plasma membrane structure of cells and organelles, lipid metabolism, and the production of lipid derivatives as cell signaling mediators are desired topics. Submissions directly related to cardiovascular physiology in health and disease are preferred but topics detailing the influence of mechanical stimuli on cellular lipids in any context will be considered. Articles describing protein-lipid interactions that play a role in mechanobiology are highly encouraged. Reviews should be mindful of methodological approaches used across fields and should include a critical analysis of findings and conclusions from studies discussed. Original work is welcome so long as it advances our understanding of how lipids respond to and are impacted by biophysical forces. In addition, we welcome timely articles relevant to atherosclerosis and methodology aimed at investigating lipids in health and disease.
Keywords: lipids, phospholipids, phosphoinositides, plasma membrane, mechanosensation, mechanoactivation, mechanotransduction, cell signaling lipids, lipid metabolism
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
