About this Research Topic
Almost 40 years have passed since the discovery of human immunodeficiency virus type 1 (HIV-1) as a major etiological agent for human acquired immunodeficiency syndrome (AIDS). While it appears to be less pathogenic and transmittable than HIV-1, HIV-2 is also a causative virus for AIDS. As all virologists and scientists in the relevant research fields recognize, the HIV-1 and HIV-2 studies, especially those on HIV-1, have been the main engine and driving force for the progression of virology and its related disciplines.
Accumulated evidence has demonstrated that HIV-1 and HIV-2 originated from simian immunodeficiency viruses (SIVs) persistent in non-human primates in Africa. HIV-1 is well known to be strictly tropic for humans as a most outstanding virus property. The process for its emergence in human populations is a critical scientific issue for a wide variety of virologists to solve experimentally and/or in silico. Similarly, its unique and marked tropism for natural target cells has been a major subject for investigation.
Even if we only talk about the basic science, we keep learning the contemporary biology through the HIV-1 virology established so far. We now know much more about the functional and structural details of viral proteins, virus species tropism, cellular tropism, adaptive mutations and evolution, virus-host conflict and interaction, viral immunology, virus spread and transmission among populations, viral persistence, etc. As is evident from currently published reports and articles, relevant HIV/SIV studies of high biological significance are actively ongoing now. The HIV/SIV study always generates biologically important concepts and also promotes technological innovations for scientific research. It is about time in this challenging period for fighting against SARS-CoV-2 to sum up our achievements on HIV/SIV studies so far and to seriously consider what future projects should be.
The subjects covered in this Research Topic include, but are not limited to:
- Biology and molecular biology of HIV/SIV
- HIV/SIV genetics
- Tropism of HIV/SIV
- Cellular factors interacting with HIV/SIV
- HIV/SIV mutation, adaptation, evolution
- Structural and functional analysis of HIV/SIV genomes and proteins
- Model studies on HIV/SIV replication and pathogenicity
We accept the submissions of the following article types: Original Research, Brief Research Report, Review, Mini Review, Perspective, and Opinion. We are looking forward to receiving your highly motivated contributions.
Accumulated evidence has demonstrated that HIV-1 and HIV-2 originated from simian immunodeficiency viruses (SIVs) persistent in non-human primates in Africa. HIV-1 is well known to be strictly tropic for humans as a most outstanding virus property. The process for its emergence in human populations is a critical scientific issue for a wide variety of virologists to solve experimentally and/or in silico. Similarly, its unique and marked tropism for natural target cells has been a major subject for investigation.
Even if we only talk about the basic science, we keep learning the contemporary biology through the HIV-1 virology established so far. We now know much more about the functional and structural details of viral proteins, virus species tropism, cellular tropism, adaptive mutations and evolution, virus-host conflict and interaction, viral immunology, virus spread and transmission among populations, viral persistence, etc. As is evident from currently published reports and articles, relevant HIV/SIV studies of high biological significance are actively ongoing now. The HIV/SIV study always generates biologically important concepts and also promotes technological innovations for scientific research. It is about time in this challenging period for fighting against SARS-CoV-2 to sum up our achievements on HIV/SIV studies so far and to seriously consider what future projects should be.
The subjects covered in this Research Topic include, but are not limited to:
- Biology and molecular biology of HIV/SIV
- HIV/SIV genetics
- Tropism of HIV/SIV
- Cellular factors interacting with HIV/SIV
- HIV/SIV mutation, adaptation, evolution
- Structural and functional analysis of HIV/SIV genomes and proteins
- Model studies on HIV/SIV replication and pathogenicity
We accept the submissions of the following article types: Original Research, Brief Research Report, Review, Mini Review, Perspective, and Opinion. We are looking forward to receiving your highly motivated contributions.
Keywords: HIV/SIV, viral genomes, viral proteins, replication, evolution, pathogenicity, tropism, cell factors
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
