About this Research Topic
In terms of inflammation, the study of pro-inflammatory immune-mediated activities has almost entirely dominated IBD pathogenesis research. However, the evaluation of immune responses to IBD must be analyzed also in the light of microbiome-derived results in order to consider the mechanisms of tissue injury. Indeed, the past two decades have seen an increase in studies suggesting the role of gut microbiota (GM), diet, intestinal barrier function, and mucosal immune response as key elements in IBD development, affecting the impaired cross-talk between GM and immune cells. Indeed, several probiotic organisms have been shown to increase the cytotoxic function of natural killer cells and macrophage phagocytosis, as well as mediate the adaptive immune responses elicited by subsets of dendritic cells (DCs), B- and T-cells, and enterocytes, favoring the regulation of gut homeostasis. However, despite the enormous progress that has been made, our knowledge of the specific microbiota members that mediate these effects and the mechanisms underlying these interactions in IBD is rudimentary. Microbiota, in addition to its direct interaction with mucosal structures, can also control host immunity by utilizing soluble chemical mediators, including cell wall elements, exopolysaccharides, short-chain fatty acids, conjugated linoleic acid, bacteriocins, extracellular bacterial proteins, and bioactive peptides. Bioactive peptides obtained from food, gut microbiota, or probiotics have been identified as immunomodulatory compounds in this regard.
This Research Topic therefore aims to collect Original Research and Review articles concerning new insights into the immunome and immunomodulation in IBD. Potential topics include, but are not limited to, the following areas of research:
• Investigation of immunome in IBD in the context of microbiome-derived effects
• Breakthroughs in the current understanding of the immunomodulation role in IBD pathogenesis, prognosis and treatment
• The prospect of IBD immunome in personalized medicine
Keywords: IBD, SCFA, Microbiome, Inflammation, immunity, immunomodulation, immunome
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.