About this Research Topic
Acute Heart Failure (HF) is one of the leading causes of urgent hospitalizations of patients with various cardiovascular diseases. Acute HF is a condition that requires prompt assessment and adequate management. Despite significant burden of acute HF in cardiovascular care, the diagnostic and treatment algorithms are still various substantially across the hospitals and hospital mortality remains to be high and not changed over recent decades. Therefore, risk stratification tools, including coronary anatomy, heart-lung interaction, biomarkers, are not still universally recommended and require to be widely investigated. In this context, there is a need to avoid disproportionately focusing on separate failing ventricle and sole cause of the event.
The aim of this Research Topic is to summarize the knowledge about multiple specific pathophysiologic mechanisms, which may be involved in acute HF occurrence and development, as well as to discuss current controversial and promising diagnostic and treatment approaches to therapy of the condition to make them far more adequate and much more effective in the term of clinical outcomes. Understanding the multifaceted etiology of acute HF, pre-existing comorbid conditions, and crucial underlying mechanisms, such as inter-chambers’ interaction, atrial and ventricular dyssynchrony, arrhythmogenesis, pressure / volume overload, target organ hypoperfusion and damage, congestion, neurohumoral and inflammatory activation, altered cardiovascular reparation, intravascular coagulation and embolic complications, may comprehensively improve the clinical outcomes. Yet, myocardial structure and function, altered coronary anatomy, shift-shaped hemodynamics, may be potent factors required to be swiftly identified so that acute HF could be managed optimally. Moreover, the adoption of diagnostic modalities, such as X-ray, MRI / CT and ultrasonography technologies, as well as novel approaches to acute and chronic mechanical circulatory support driven by invasive hemodynamic assessment for acute care is a promising approach for a broad range of specialties.
This Research Topic welcomes review papers and original research on the following themes but is not limited to them:
• Heart failure pathogenesis
• Microvascular inflammation and adverse cardiac remodeling
• Oxidative stress and myocardial fibrosis
• Hemodynamics and hypoperfusion of target organs
• Emerging diagnostic and therapeutic interventions
• Concept of left ventricular unloading
• New and old surrogate biomarkers
• Imaging in acute heart failure
• Development of predictive models
The aim of this Research Topic is to summarize the knowledge about multiple specific pathophysiologic mechanisms, which may be involved in acute HF occurrence and development, as well as to discuss current controversial and promising diagnostic and treatment approaches to therapy of the condition to make them far more adequate and much more effective in the term of clinical outcomes. Understanding the multifaceted etiology of acute HF, pre-existing comorbid conditions, and crucial underlying mechanisms, such as inter-chambers’ interaction, atrial and ventricular dyssynchrony, arrhythmogenesis, pressure / volume overload, target organ hypoperfusion and damage, congestion, neurohumoral and inflammatory activation, altered cardiovascular reparation, intravascular coagulation and embolic complications, may comprehensively improve the clinical outcomes. Yet, myocardial structure and function, altered coronary anatomy, shift-shaped hemodynamics, may be potent factors required to be swiftly identified so that acute HF could be managed optimally. Moreover, the adoption of diagnostic modalities, such as X-ray, MRI / CT and ultrasonography technologies, as well as novel approaches to acute and chronic mechanical circulatory support driven by invasive hemodynamic assessment for acute care is a promising approach for a broad range of specialties.
This Research Topic welcomes review papers and original research on the following themes but is not limited to them:
• Heart failure pathogenesis
• Microvascular inflammation and adverse cardiac remodeling
• Oxidative stress and myocardial fibrosis
• Hemodynamics and hypoperfusion of target organs
• Emerging diagnostic and therapeutic interventions
• Concept of left ventricular unloading
• New and old surrogate biomarkers
• Imaging in acute heart failure
• Development of predictive models
Keywords: acute heart failure, cardiogenic shock, underlying mechanisms, ventricular dysfunction, ventricular function, diagnosis, intensive care, prognosis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
