About this Research Topic
The breadth of TDP-43 dyshomeostasis and proteinopathy in neurodegeneration is ever expanding and TDP-43 inclusions have now been reported in several diseases such as ALS, FTLD, Alzheimer’s and Parkinson’s. Thus, understanding and elucidating the intricacies of TDP-43 pathology seems important towards unearthing the convergent toxic pathways across different neurodegenerative diseases.
Contributions that address the mechanisms of TDP-43 misfolding, dyshomeostasis and cytotoxicity using approaches such as genetics, proteomics, genomics, in vitro models, biochemistry and cell biology etc. in any model system are welcomed. As well, manuscripts describing novel strategies to target TDP-43 proteinopathy towards therapeutics of neuro-degenerative diseases, will also be considered.
Keywords: TDP-43, ALS, FTLD, Proteionopathy, Misfolding, Neurodegenerative Diseases, Alzheimer’s, Therapeutics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.