About this Research Topic
Interactions between the microbiota and immune cells can form adaptive immune responses in the host. In autoimmune disease, microbial contributions to disease initiation and propagation are plausible and likely. Dysbiosis appears to be a common feature of connective tissue diseases and primary vasculitides, according to studies of the human skin, oral, subgingival, intestinal, nasal, lung, and vascular microbiome. Significant variability in observed microbial composition occurs across published studies, which may indicate variations in the patient population, disease phenotype and activity, treatment, or study design. To maximize the comparability and validity of microbiome research in the analysis of systemic autoimmune diseases, efforts in the standardization of workflow and methodology are needed. Identifying possible microbial targets in the treatment of preclinical and proven autoimmune diseases like vasculitis would require combining descriptive studies with hypothesis-driven studies.
Our Research Topic aims to clarify the relationship between the microbiome and lymphocyte subsets such as T cells, B cells, NK cells, Th cells, Tfh cells, Tfr cells, Treg cells. Moreover, we aim to explore mechanisms of immunologic balance result from the microbiome in autoimmune diseases like vasculitis.
We welcome the submission of Original Research, Systemic Review, Methods, Review, and Hypothesis and Theory on this scope but not limited to topics below:
• Therapeutic approaches targeting the gut microbiota for vasculitis.
• The role of gut microbiota and its metabolites in the pathophysiology of vasculitis.
• Prefer studies that mechanistically link microbiota to disease-related changes in immune cells.
Please note that a discovery cohort and replication cohort are required for pure association-based studies.
Our Research Topic aims to clarify the relationship between the microbiome and lymphocyte subsets such as T cells, B cells, NK cells, Th cells, Tfh cells, Tfr cells, Treg cells. Moreover, we aim to explore mechanisms of immunologic balance result from the microbiome in autoimmune diseases like vasculitis.
We welcome the submission of Original Research, Systemic Review, Methods, Review, and Hypothesis and Theory on this scope but not limited to topics below:
• Therapeutic approaches targeting the gut microbiota for vasculitis.
• The role of gut microbiota and its metabolites in the pathophysiology of vasculitis.
• Prefer studies that mechanistically link microbiota to disease-related changes in immune cells.
Please note that a discovery cohort and replication cohort are required for pure association-based studies.
Keywords: Intestinal microbiota; Regulatory T cells; Immunoregulation; Autoimmunity; Vasculitis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
