About this Research Topic
RNA editing is a pivotal co-/post-transcriptional process perturbing the RNA in eukaryotic cells. RNA editing could occur in coding regions and noncoding regions, affecting the recoding of proteins, RNA splicing and stability. Adenosine to inosine (A-to-I) editing catalyzed by adenosine deaminases acting on RNA (ADAR) is the most dominant (~90%) RNA editing events in mammals. Since inosine is considered as guanosine because of the structure similarity in the processes of translation and in vitro polymerase reaction, the A-to-I editing impact on development, disease initiation and progression and cancer. Despite there are extensive studies of RNA editing in human tissues, cancer development and the neural system, the study of the RNA editing in other species apart from human and mouse were still limited. On the other side, regulation of RNA editing in diseases such as disorders in cardiovascular, immune and metabolism systems need to be investigated. Besides RNA editing, general RNA modifications including, m6A and pseudouridine, have emerged as a critical layer for gene expression regulation, known as the epitranscriptome, attracting the best scientists globally.
In this Research Topic, we aim to gather articles from RNA editing studies in different species including viruses, microbes, plants, and animals to study the role of RNA editing in development process and in multiple human diseases. We welcome original research, brief research reports, and review articles covering the discovery of RNA editing, functional analysis, mechanisms related to RNA editing. We also welcome studies concerning the general epitranscriptome, which contains more than 100 different types of RNA modifications, using experimental and/or computational approaches.
The subjects we wish to cover will include but are not limited to the following:
- Discover the RNA editing in different species and reveal its role in the development process.
- Investigate the function of RNA editing in diseases.
- RNA editing in the immune response to the external stimulus.
- Find the novel possible regulators which may determine the RNA editing.
- Develop new computational tools, databases and algorithms to detect or analyses of RNA editing.
- Intergrade the RNA editing data with other data to understand the underlying mechanisms of RNA editing.
- RNA editing in single-cell level to reveal the cell type specific - RNA editing events from scRNA-seq data.
- Analysis of the general epitranscriptome, including its regulators, functional relevance and disease association, etc.
- Bioinformatics approach, statistical modelling, software, database or web server for decoding the RNA editing and modifications.
- Reviews on the study progress of RNA editing and modifications
In this Research Topic, we aim to gather articles from RNA editing studies in different species including viruses, microbes, plants, and animals to study the role of RNA editing in development process and in multiple human diseases. We welcome original research, brief research reports, and review articles covering the discovery of RNA editing, functional analysis, mechanisms related to RNA editing. We also welcome studies concerning the general epitranscriptome, which contains more than 100 different types of RNA modifications, using experimental and/or computational approaches.
The subjects we wish to cover will include but are not limited to the following:
- Discover the RNA editing in different species and reveal its role in the development process.
- Investigate the function of RNA editing in diseases.
- RNA editing in the immune response to the external stimulus.
- Find the novel possible regulators which may determine the RNA editing.
- Develop new computational tools, databases and algorithms to detect or analyses of RNA editing.
- Intergrade the RNA editing data with other data to understand the underlying mechanisms of RNA editing.
- RNA editing in single-cell level to reveal the cell type specific - RNA editing events from scRNA-seq data.
- Analysis of the general epitranscriptome, including its regulators, functional relevance and disease association, etc.
- Bioinformatics approach, statistical modelling, software, database or web server for decoding the RNA editing and modifications.
- Reviews on the study progress of RNA editing and modifications
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
