About this Research Topic
The neurovascular unit (NVU) is a group of closely related cells and extracellular matrix components, including neurons, astrocytes, microglia, endothelial cells, pericytes, and smooth muscle cells. These cells and extracellular components form unique and complex multicellular structures that maintain the neurological homeostasis in the central nervous system by regulating regional cerebral blood flow (CBF) and nutrient delivery. After traumatic injuries of the central nervous system (CNS), the disruption of NVU leads to the dysregulation of neural activity, causing neuronal dysfunction and cognitive impairment. Understanding the disruption and regeneration of NVU aids in the prevention and treatment of neurological dysfunction after CNS injury.
This Research Topic aims to gain a deep understanding of neurovascular microstructure remodeling processes and neurovascular repair mechanisms following CNS injuries. We also would like to investigate the molecular and cellular mechanisms of NVU interaction during CNS repair, as well as the function of NVU regeneration in the rehabilitation of cognitive dysfunction following CNS damage. Targeting NVU regeneration sheds new light on the development of novel therapeutic approaches for treating CNS injuries.
All Original Research Articles and Reviews that focus on, but are not limited to, the topics mentioned below are welcome:
- Utilizing visualization tools to analyze neurovascular microstructures remodeling process during CNS repair.
- The cellular interaction within NVU during CNS regeneration
- The heterogeneity of multicellular component of NVU during CNS regeneration (single-cell sequencing and spatial transcriptome analysis)
- Epigenetic regulation of neurovascular regeneration after CNS injury.
- Novel therapeutic tools of targeting neurovascular regeneration after CNS injury (exosome, aptamer, antisense oligodeoxynucleotide, etc)
- Neurovascular tissue engineering or Spinal Cord-Like Tissue application for targeting neurovascular regeneration after CNS injury.
This Research Topic aims to gain a deep understanding of neurovascular microstructure remodeling processes and neurovascular repair mechanisms following CNS injuries. We also would like to investigate the molecular and cellular mechanisms of NVU interaction during CNS repair, as well as the function of NVU regeneration in the rehabilitation of cognitive dysfunction following CNS damage. Targeting NVU regeneration sheds new light on the development of novel therapeutic approaches for treating CNS injuries.
All Original Research Articles and Reviews that focus on, but are not limited to, the topics mentioned below are welcome:
- Utilizing visualization tools to analyze neurovascular microstructures remodeling process during CNS repair.
- The cellular interaction within NVU during CNS regeneration
- The heterogeneity of multicellular component of NVU during CNS regeneration (single-cell sequencing and spatial transcriptome analysis)
- Epigenetic regulation of neurovascular regeneration after CNS injury.
- Novel therapeutic tools of targeting neurovascular regeneration after CNS injury (exosome, aptamer, antisense oligodeoxynucleotide, etc)
- Neurovascular tissue engineering or Spinal Cord-Like Tissue application for targeting neurovascular regeneration after CNS injury.
Keywords: Neurovascular Unit, CNS Injury, Spinal Cord-Like Tissue, Single Cell Sequencing, Epigenetic Regulation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
