About this Research Topic
Mitochondria serve as the powerhouse of cellular metabolisms including ATP production and regulation of the activation of downstream pathways including programmed cell death. Mitochondria are involved in various biological processes and mitochondrial dysfunction contributes to the pathogenesis of human diseases. Ferroptosis is a recently discovered form of programmed cell death, an iron-driven cell death characterized by excessive lipid peroxidation products and reactive oxygen species (ROS). Ferroptosis has been identified in a variety of pathological processes including carcinogenesis, cardiovascular diseases and degenerative diseases. Mitochondria are the main subcellular organelle for ROS production and emerging evidence has indicated that mitochondrial physiology and its safeguard mechanisms (e.g., mitophagy) regulate ferroptosis. Consequently, it is important to investigate the role of mitochondria and ferroptosis in cell fate and provide insights into their correlations.
In our Research Topic, original research and review articles that focus on but are not limited to the following topics are welcomed:
-Crosstalk between mitochondrial maintaining mechanisms (e.g., mitophagy, mitochondrial unfolded protein response) and ferroptosis.
-Crosstalk between mitochondrial respiratory function and ferroptosis.
-Mechanisms regulating mitochondrial function and ferroptosis in disease development and progression.
-Omics or systemic study of mitochondria and ferroptosis-related disorders.
-Novel therapeutics targeting mitochondrial and ferroptopic dysfunctions.
In our Research Topic, original research and review articles that focus on but are not limited to the following topics are welcomed:
-Crosstalk between mitochondrial maintaining mechanisms (e.g., mitophagy, mitochondrial unfolded protein response) and ferroptosis.
-Crosstalk between mitochondrial respiratory function and ferroptosis.
-Mechanisms regulating mitochondrial function and ferroptosis in disease development and progression.
-Omics or systemic study of mitochondria and ferroptosis-related disorders.
-Novel therapeutics targeting mitochondrial and ferroptopic dysfunctions.
Keywords: mitochondria, ferroptosis, cell fate, cell death
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
