Novel Small-Molecule Agents in Overcoming Multidrug Resistance in Cancers

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ORIGINAL RESEARCH

Published on 13 May 2022

DHW-221, a Dual PI3K/mTOR Inhibitor, Overcomes Multidrug Resistance by Targeting P-Glycoprotein (P-gp/ABCB1) and Akt-Mediated FOXO3a Nuclear Translocation in Non-small Cell Lung Cancer

Mingyue Liu
Chang Xu
Xiaochun Qin
Wenwu Liu
Deping Li
Hui Jia
Xudong Gao
Yuting Wu
Qiong Wu
6 more
Qingchun Zhao

doi 10.3389/fonc.2022.873649

2,706 views
14 citations

REVIEW

Published on 06 May 2022

Research Advances on Anti-Cancer Natural Products

Meng Guo
Jie Jin
Dong Zhao
Zheng Rong
Lu-Qi Cao
Ai-Hong Li
Xiao-Ying Sun
Li-Yi Jia
Yin-Di Wang
7 more
Hui-Ling Cao

doi 10.3389/fonc.2022.866154

4,816 views
33 citations

EDITORIAL

Published on 04 May 2022

Editorial: Novel Small-Molecule Agents in Overcoming Multidrug Resistance in Cancers

Qingbin Cui
Cong Wang
Leli Zeng
Qian-Xiong Zhou
Ying-Fang Fan

doi 10.3389/fchem.2022.921985

2,054 views
6 citations

ORIGINAL RESEARCH

Published on 25 Apr 2022

Novel MDM2 Inhibitor XR-2 Exerts Potent Anti-Tumor Efficacy and Overcomes Enzalutamide Resistance in Prostate Cancer

Meng Wu
Jingyi Cui
Huimin Hou
Ying Li
Shengjie Liu
Li Wan
Lili Zhang
Wei Huang
Gaoyuan Sun
3 more
Ming Liu

doi 10.3389/fphar.2022.871259

2,702 views
6 citations

ORIGINAL RESEARCH

Published on 21 Apr 2022

Meclofenamic Acid Restores Gefinitib Sensitivity by Downregulating Breast Cancer Resistance Protein and Multidrug Resistance Protein 7 via FTO/m6A-Demethylation/c-Myc in Non-Small Cell Lung Cancer

Hui Chen
Bin Jia
Qiang Zhang
Yu Zhang

doi 10.3389/fonc.2022.870636

2,426 views
34 citations

ORIGINAL RESEARCH

Published on 06 Apr 2022

Design, Synthesis, and Biological Evaluation of [1,2,4]triazolo[4,3-a] Pyrazine Derivatives as Novel Dual c-Met/VEGFR-2 Inhibitors

Xiaobo Liu
Yuzhen Li
Qian Zhang
Qingshan Pan
Pengwu Zheng
Xinyang Dai
Zhaoshi Bai
Wufu Zhu

doi 10.3389/fchem.2022.815534

2,216 views
13 citations

REVIEW

Published on 01 Apr 2022

Research Advances on Matrine

Xiao-Ying Sun
Li-Yi Jia
Zheng Rong
Xin Zhou
Lu-Qi Cao
Ai-Hong Li
Meng Guo
Jie Jin
Yin-Di Wang
8 more
Hui-Ling Cao

doi 10.3389/fchem.2022.867318

8,569 views
48 citations

ORIGINAL RESEARCH

Published on 01 Apr 2022

Ribociclib Inhibits P-gp-Mediated Multidrug Resistance in Human Epidermoid Carcinoma Cells

Lei Zhang
Biwei Ye
Yunfeng Lin
Yi-Dong Li
Jing-Quan Wang
Zhuo Chen
Feng-Feng Ping
Zhe-Sheng Chen

doi 10.3389/fphar.2022.867128

2,286 views
7 citations

REVIEW

Published on 28 Mar 2022

Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance

Zhuo-fen Deng
Irina Bakunina
Hua Yu
Jaehong Han
Alexander Dömling
Maria-José U Ferreira
Jian-ye Zhang

doi 10.3389/fphar.2022.815603

2,110 views
2 citations

ORIGINAL RESEARCH

Published on 25 Mar 2022

Combining EGFR-TKI With SAHA Overcomes EGFR-TKI-Acquired Resistance by Reducing the Protective Autophagy in Non-Small Cell Lung Cancer

Peijun Cao
Yongwen Li
Ruifeng Shi
Yin Yuan
Hao Gong
Guangsheng Zhu
Zihe Zhang
Chen Chen
Hongbing Zhang
3 more
Jun Chen

doi 10.3389/fchem.2022.837987

3,584 views
12 citations

MINI REVIEW

Published on 11 Mar 2022

A Mini-Review of Flavone Isomers Apigenin and Genistein in Prostate Cancer Treatment

Xiaozhen Ji
Kai Liu
Qingyue Li
Qun Shen
Fangxuan Han
Qingmei Ye
Caijuan Zheng

doi 10.3389/fphar.2022.851589

4,597 views
22 citations

ORIGINAL RESEARCH

Published on 08 Mar 2022

The Resistance of Cancer Cells to Palbociclib, a Cyclin-Dependent Kinase 4/6 Inhibitor, is Mediated by the ABCB1 Transporter

Han Fu
Zhuo-Xun Wu
Zi-Ning Lei
Qiu-Xu Teng
Yuqi Yang
Charles R. Ashby
Yixiong Lei
Yuyin Lian
Zhe-Sheng Chen

doi 10.3389/fphar.2022.861642

3,623 views
11 citations

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Frontiers in Chemistry

Medicinal and Pharmaceutical Chemistry

Participating Journals

Frontiers in Oncology
- Pharmacology of Anti-Cancer Drugs
- 3.5 impact factor
- 6.2 citescore
Frontiers in Pharmacology
- Pharmacology of Anti-Cancer Drugs
- 4.4 impact factor
- 7.8 citescore

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Articles

DHW-221, a Dual PI3K/mTOR Inhibitor, Overcomes Multidrug Resistance by Targeting P-Glycoprotein (P-gp/ABCB1) and Akt-Mediated FOXO3a Nuclear Translocation in Non-small Cell Lung Cancer

Research Advances on Anti-Cancer Natural Products

Editorial: Novel Small-Molecule Agents in Overcoming Multidrug Resistance in Cancers

Novel MDM2 Inhibitor XR-2 Exerts Potent Anti-Tumor Efficacy and Overcomes Enzalutamide Resistance in Prostate Cancer

Meclofenamic Acid Restores Gefinitib Sensitivity by Downregulating Breast Cancer Resistance Protein and Multidrug Resistance Protein 7 via FTO/m6A-Demethylation/c-Myc in Non-Small Cell Lung Cancer

Design, Synthesis, and Biological Evaluation of [1,2,4]triazolo[4,3-a] Pyrazine Derivatives as Novel Dual c-Met/VEGFR-2 Inhibitors

Research Advances on Matrine

Ribociclib Inhibits P-gp-Mediated Multidrug Resistance in Human Epidermoid Carcinoma Cells

Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance

Combining EGFR-TKI With SAHA Overcomes EGFR-TKI-Acquired Resistance by Reducing the Protective Autophagy in Non-Small Cell Lung Cancer

A Mini-Review of Flavone Isomers Apigenin and Genistein in Prostate Cancer Treatment

The Resistance of Cancer Cells to Palbociclib, a Cyclin-Dependent Kinase 4/6 Inhibitor, is Mediated by the ABCB1 Transporter

Frontiers in Chemistry

Medicinal and Pharmaceutical Chemistry

Participating Journals

Frontiers in Oncology

Pharmacology of Anti-Cancer Drugs

Frontiers in Pharmacology

Pharmacology of Anti-Cancer Drugs