Regulation of Mitochondrial Function on Animal Diseases

Mitochondria are widely distributed in a variety of eukaryotic cells and play important roles in energy metabolism, calcium transporters, cell proliferation and differentiation, free radical production, senescence, apoptosis and autophagy, etc. Mitochondrial gene mutations, respiratory chain defects, mitochondrial membrane changes and other factors can affect the normal function of the whole cell, which leads to the occurrence of diseases. Several studies have shown that mitochondrial dysfunction, mitochondrial iron metabolism, mitochondrial apoptosis and autophagy, mitochondrial RNA transcription processing and modification are involved in the animal disease processes relating to the occurrence and development, such as poisoning disease, nerve endocrine disease, bone disease, tumor diseases and carbohydrate metabolism disorder, etc. It is not only one of the causes of disease, but also early signs of the disease. Thorough understanding of main mitochondrial useful properties (associated with energy and redox control, and cellular signaling) is probably desired to know mitochondrial procedures primary differences in animal routine.

This study focuses on the role of mitochondria in animal disease, the processes may include mitochondrial oxidative stress and energy metabolism, cell autophagy and apoptosis, cell organelle interactions, cell proliferation and metabolism regulation, calcium ion transport, inflammation and immunity, the interaction of mitochondrial and nuclear genomes (mitochondrial DNA, non-coding RNA), metabolomics, gut microbiota, etc. This research also spotlights the impacts of mitochondria on animal nutrition, metabolic diseases, poisoning diseases, etc.

We welcome Mini-Reviews, full-length Reviews, and Original Research papers. Our Research Topic includes, but is not necessarily limited to:
• Mechanisms of cell damage mediated by mitochondrial dysfunction: energy metabolism disorders (mitochondrial membrane destruction, respiratory chain inhibition, reduced enzyme activity, iron metabolism, mitochondrial DNA damage), disruption of calcium-based homeostasis, and production of reactive oxygen species.
• To investigate the role of autophagy and apoptosis in animal diseases based on mitochondrial regulatory pathways
• Multicellular communication: In animal diseases, the regulatory mechanisms between endoplasmic reticulum, lysosome, Golgi apparatus and mitochondria are included.
• Mitochondrial genome and animal disease (parasites identification, mtDNA, miRNA, etc.)
• Mitochondrial Contribution to Animal Performance
• Adaptations to the intracellular conditions experienced by the mitochondria
• Linking mitochondrial function to components of fitness
• Mitochondrial responses to environmental variations