Role of Pyroptosis and Ferroptosis in the Angiopathy

Angiopathy (macroangiopathy or microangiopathy) is the generic term for a disease of the blood vessels which often occur in chronic metabolic diseases. Angiopathy may cause atherosclerosis and decrease of blood flow through stenosis or clot formation which impairs the flow of oxygen to cells and biological tissues. Therefore preventing the occurrence and development of Angiopathy is very important to improve health. Over the past few decades, some experimental studies have provided evidence that the occurrence of angiopathy is closely related to the pyroptosis and ferroptosis pathways in pathological processes, including ischemic heart disease, stroke, retinopathy, nephropathy and so on. Despite extensive studies, however, the molecular pathways involved in Angiopathy associated pyroptosis and ferroptosis pathway are still not completely understood.

This Research Topic aims to serve as a resource for biomedical investigators at all levels, both those engaged in basic research as well as those involved in clinical practice. It hopes to provide new basic mechanisms and of novel developments in the progressive theory of the role of pyroptosis and ferroptosis in Angiopathy pathophysiology, contributing to a more comprehensive knowledge of the disease. Accordingly, we welcome investigators to contribute original research and review articles that will help elucidate the molecular pathways underlining this complex iatrogenic condition. We encourage the submission of in vitro, ex vivo, in vivo, clinical studies and reviews describing the pyroptosis and ferroptosis, the pathophysiological mechanisms underlying these associations and the modulatory roles of novel pharmaceutical compounds.