About this Research Topic
The failures of the last decades to develop effective and evidence based therapeutics in TBI are partly due to lack of high fidelity models of TBI due to our incomplete understanding of interactions between physical and biological events.
The extensive use of explosive blast as weapon or as mean of terror has been a “game changer”. Explosive blast is not only a highly complex type of physical forces but it appears that the resulting TBI is a highly complex kind of injury. The new public awareness about TBI has been further increased by reports and studies related to mild athletic or sport injuries (concussions), which are often repeated.
Our goal with launching this Research Topic is to review and summarize the most current knowledge about the physical components that cause the various forms of TBIs; in biomechanics of the brain, the various biological structures affected by physical forces, and their molecular and cellular responses to mechanical insults. Importantly, we would like to encourage presentations of ongoing original works in this Research Topic.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.