About this Research Topic
Bone is a dynamic tissue characterized by continuous remodeling based on resorption and formation activities. Indeed, the integrity of skeleton is maintained by a tight cross-talk between bone cells, osteoclasts, osteoblasts and osteocytes. However, in the last 10 years several studies suggested that the bone remodeling activity is essential to exert the endocrine function of the skeleton, regulating energy expenditure, insulin secretion, male fertility, appetite, cognitive behavior and anxiety.
It is now well established that the skeleton regulates the whole body physiology, and that bone diseases could lead to alterations of other organs or systems. The study of the molecular mechanisms regulating bone cells differentiation and activity is relevant to identify new molecular pathways of disease and therapeutic treatments to restore the bone remodeling activity.
We welcome investigators to contribute original research articles as well as review articles that will describe the molecular mechanisms leading to the onset of bone diseases and innovative treatments for skeletal diseases.
In this Research Topic, we would like to include Original Research and Review articles. Areas to be covered in this Research Topic may include, but are not limited to:
- Understanding the molecular mechanisms of bone diseases, including rare bone diseases and osteosarcoma
- Identification of new therapeutic approaches for bone disorders
- Evaluation of new biomarkers for bone diseases
- Dissecting the endocrine role of the skeleton and the crosstalk with other organs.
Keywords: Bone, Bone disease, Osteoporosis, Endocrine, Osteoclast, Osteoblast, Osteocyte
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
