About this Research Topic
Our brain is highly plastic not only to sensory stimuli but also to environmental, chemical and biological stressors. Molecules in brain cells must be altered and adapted in response to external challenges to maintain stability at the cellular and network levels.
Individual differences in molecular and cellular adaptations possibly drive susceptibility or resilience in response to risk factors and subsequent disease progression. Thus, studies of such compensatory mechanisms would provide a great opportunity of identifying disease mechanisms, new biomarkers and therapeutic targets.
This research topic includes molecular and cellular adaptations to physiological stimuli as well as risk factors for neurodegeneration and psychiatric diseases. Both in vitro and in vivo studies of brain cells will be well considered. Cell-type-specific approaches and mechanisms in vivo will be highly welcome. Brain cells include neurons, neuroglia and vascular cells.
Submissions are welcome for the following article types: original research, review, mini-reviews, innovative research protocol/method, opinion and hypothesis. We particularly welcome contributions that include, but are not limited to, the following topics:
- Brain cell’s compensatory mechanisms in response to protein aggregates such as Aβ, tau or α-synuclein aggregates
- Brain cell’s compensatory mechanisms in response to brain injury such as traumatic brain injury
- Brain cell’s compensatory mechanisms in response to emotional stress
- Brain cell’s compensatory mechanisms in response to pharmacological disturbances such as drugs of abuse
Individual differences in molecular and cellular adaptations possibly drive susceptibility or resilience in response to risk factors and subsequent disease progression. Thus, studies of such compensatory mechanisms would provide a great opportunity of identifying disease mechanisms, new biomarkers and therapeutic targets.
This research topic includes molecular and cellular adaptations to physiological stimuli as well as risk factors for neurodegeneration and psychiatric diseases. Both in vitro and in vivo studies of brain cells will be well considered. Cell-type-specific approaches and mechanisms in vivo will be highly welcome. Brain cells include neurons, neuroglia and vascular cells.
Submissions are welcome for the following article types: original research, review, mini-reviews, innovative research protocol/method, opinion and hypothesis. We particularly welcome contributions that include, but are not limited to, the following topics:
- Brain cell’s compensatory mechanisms in response to protein aggregates such as Aβ, tau or α-synuclein aggregates
- Brain cell’s compensatory mechanisms in response to brain injury such as traumatic brain injury
- Brain cell’s compensatory mechanisms in response to emotional stress
- Brain cell’s compensatory mechanisms in response to pharmacological disturbances such as drugs of abuse
Keywords: Repair, Compensatory Response, Molecular Pathway, Specific Cell-type, Disease Susceptibility, Disease Resilience, Protein Aggregates, Emotional Stress, Pharmacological Disturbance, Homeostasis, Neurons, Neuroglia, Neurovascular Function
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
