About this Research Topic
In this Research Topic, we aim to gather studies bringing new insights on the multifacets of tumor heterogeneity and its impact on amino-acids (AAs) metabolism. Novel studies deciphering tumor metabolic complexity and/or its interplay with oncogenic activation or suppression are welcome. A particular consideration will be given to papers that would provide scientific advances in AAs metabolism, metabolic adaptation and oncogenic activation during spontaneous tumor development or treatment escape. Toward these aims, we encourage submissions that focus on mechanistic hints and the development and validation of novel anticancer approaches, which include, but are not limited to, AAs metabolism, hypoxia, tumor heterogeneity, genetic and epigenetic regulations dependent on AAs-derived metabolites and combination therapies that explore the targeting of signaling cascades and tumor metabolism.
Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in Frontiers in Oncology.
Keywords: Metabolism, Amino Acid, Cancer, Tumor Heterogeneity, Hypoxia
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.