About this Research Topic
Ischemic heart disease (IHD) is one of the leading causes of death in the world. The rupture of coronary atherosclerotic plaque that leads to coronary artery stenosis or thrombosis occlusion, usually called acute myocardial ischemia (AMI), deprives the oxygen and nutrients from cardiac cells and results in cell death. Mitochondrial dysfunction defined as the imbalance of fission and fusion, loss of mitochondrial membrane potential and mitochondrial-related apoptosis, is the major cause of cardiomyocyte death after AMI. Therefore, the investigation in the research field of mitochondrial dynamics of ischemic heart may provide novel strategies in clinical setting for improving the prognosis of AMI patients.
In this research topic, we will focus on the key factors leading to mitochondrial metabolic disorder, impaired energy balance and the disruption of mitochondrial structure, which includes mitochondrial oxidative stress, mitochondrial dynamics such as fission, fusion and mitophagy, mtDNA mutations and the transport of mitochondrial ions and metabolites. We can speculate that new strategies and novel therapeutic target for the treatment of ischemic heart disease (IHD) would be possible based on the publications of this series of research topics.
This research topics focuses on mitochondrial metabolism, which includes discovery of new mitochondrial pathogenic genes or proteins, new therapies based on improving myocardial mitochondrial function, or new mechanisms for cardiovascular disease caused by mitochondrial metabolic disorder. And submitted manuscripts should be the basic research in cardiovascular disease.
The research topic covers the following topics, but not limited to:
1) Mitochondrial oxidative stress, mitophagy and mitochondrial respiratory chain in the research of ischemic heart diseases, cardiomyophathy, obesity-related diseases.
2) Mitochondrial fission and fusion related mitochondrial dynamics in ischemic heart diseases.
3) Mitochondrial homeostasis in the control of cardiomyopathy, cardiac fibrosis, and heart failure.
4) Epigenetic regulation of mitochondrial function, including methylation, acetylation, phosphorylation, palmitoylation, glycosylation and SUMOylation.
5) Mitochondrial DNA (mtDNA) mutation in cardiac genetic diseases.
6) Mitochondrial metabolites serve as biomarkers for diagnosis of cardiovascular disease.
7) Mitochondrial protective drug discovery (Including the biological molecules, chemical compounds, natural plants and etc).
In this research topic, we will focus on the key factors leading to mitochondrial metabolic disorder, impaired energy balance and the disruption of mitochondrial structure, which includes mitochondrial oxidative stress, mitochondrial dynamics such as fission, fusion and mitophagy, mtDNA mutations and the transport of mitochondrial ions and metabolites. We can speculate that new strategies and novel therapeutic target for the treatment of ischemic heart disease (IHD) would be possible based on the publications of this series of research topics.
This research topics focuses on mitochondrial metabolism, which includes discovery of new mitochondrial pathogenic genes or proteins, new therapies based on improving myocardial mitochondrial function, or new mechanisms for cardiovascular disease caused by mitochondrial metabolic disorder. And submitted manuscripts should be the basic research in cardiovascular disease.
The research topic covers the following topics, but not limited to:
1) Mitochondrial oxidative stress, mitophagy and mitochondrial respiratory chain in the research of ischemic heart diseases, cardiomyophathy, obesity-related diseases.
2) Mitochondrial fission and fusion related mitochondrial dynamics in ischemic heart diseases.
3) Mitochondrial homeostasis in the control of cardiomyopathy, cardiac fibrosis, and heart failure.
4) Epigenetic regulation of mitochondrial function, including methylation, acetylation, phosphorylation, palmitoylation, glycosylation and SUMOylation.
5) Mitochondrial DNA (mtDNA) mutation in cardiac genetic diseases.
6) Mitochondrial metabolites serve as biomarkers for diagnosis of cardiovascular disease.
7) Mitochondrial protective drug discovery (Including the biological molecules, chemical compounds, natural plants and etc).
Keywords: mitochondria, ischemia/reperfusion, cell metabolism, oxidative stress, heart failure
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
