About this Research Topic
Autophagy is an intracellular degradation process whereby cellular components are engulfed into double-membraned structures for their degradation at the lysosome. Autophagy is an evolutionary conserved pathway that is essential for maintaining the cell homeostasis and that is involved in multiple physiological and pathological conditions, including cancer. The role of autophagy in cancer is context dependent and it might have a dual role both in early stages of tumor development (by maintaining cellular homeostasis and therefore inhibiting tumorigenesis) as well as in established tumors (by sustaining tumor growth).
This Research Topic will focus on recent advances on understanding multiple aspects of autophagy regulation in cancer and its role in tumorigenesis. For example, analysis of the mutational landscape of autophagy genes in cancers, transcriptional regulation of autophagy genes, methods to determine autophagic flux in cancer cells in vitro and in vivo, development of new markers for determining autophagic flux in human samples, understanding the metabolism and the molecular signaling pathways governing cancer development and their intersection with autophagy in cancer development and progression, development of new therapies.
Topics related to the role of autophagy in cancer include, but are not limited to:
• Oncogenic signaling pathways regulating autophagy
• Structural biology
• Bioinformatic studies
• The role of the different types of autophagy in cancer (macroautophagy, microautophagy, CMA, selective autophagy)
• Understanding the biochemical reactions regulating autophagy in cancer
• New mouse models and techniques
• Metabolism
• Translational studies
• Development of new targeted therapies for cancer treatment
• Transcriptional regulation of autophagy
Types of manuscripts: Original Research, Brief Research Report, Methods, Reviews.
This collection derived from research presented at the Keystone Symposia 'Autophagy: Mechanisms and Disease', held on October 5-8, 2020.
This Research Topic will focus on recent advances on understanding multiple aspects of autophagy regulation in cancer and its role in tumorigenesis. For example, analysis of the mutational landscape of autophagy genes in cancers, transcriptional regulation of autophagy genes, methods to determine autophagic flux in cancer cells in vitro and in vivo, development of new markers for determining autophagic flux in human samples, understanding the metabolism and the molecular signaling pathways governing cancer development and their intersection with autophagy in cancer development and progression, development of new therapies.
Topics related to the role of autophagy in cancer include, but are not limited to:
• Oncogenic signaling pathways regulating autophagy
• Structural biology
• Bioinformatic studies
• The role of the different types of autophagy in cancer (macroautophagy, microautophagy, CMA, selective autophagy)
• Understanding the biochemical reactions regulating autophagy in cancer
• New mouse models and techniques
• Metabolism
• Translational studies
• Development of new targeted therapies for cancer treatment
• Transcriptional regulation of autophagy
Types of manuscripts: Original Research, Brief Research Report, Methods, Reviews.
This collection derived from research presented at the Keystone Symposia 'Autophagy: Mechanisms and Disease', held on October 5-8, 2020.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
