Molecular Mechanisms Underlying Infection-related Cardiovascular Diseases

Infection-related cardiovascular diseases mainly include septic cardiomyopathy, viral myocarditis, infective endocarditis, and rheumatic heart disease. The mechanism may be related to the direct effect of pathogens and the indirect effect of the abnormal immune responses. However, there is still a lack of highly specific treatment for these diseases. Up to now, studies have found that microRNAs (miR-125b, miR-126, and miR-155, etc.) and long non-coding RNAs (lncRNA AK085865, lncRNA HOTAIR, and lncRNA MIAT, etc.) regulate the progression of infection-related cardiovascular diseases. Besides, the function of circulating stem (progenitor) cells, vascular endothelial cells, cardiomyocytes, and immune cells in sepsis and myocarditis changes during the process. Although some progress has been made in uncovering the mechanism of these diseases in recent years, there is still a lack of major breakthroughs in improving clinical treatment methods.

The aim of this Research Topic focuses on the new molecular mechanisms underlying infection-related cardiovascular diseases, which gives the theoretical and experimental basis for new treatment options in the future.
We welcome the submission of Original Research, Review, and General Commentary on but not limited to the topics below in the development of infection-related cardiovascular diseases (septic cardiomyopathy, viral myocarditis, infective endocarditis, rheumatic heart disease, etc.):

• The role of stem (progenitor) cells;
• New regulatory role of non-coding RNAs (miRNAs, lncRNAs, circRNAs, etc.);
• New regulatory mechanism of immune cells ;
• The mechanism of vascular injury repair;
• The role of epigenetic regulation;
• Any other molecular mechanisms.