About this Research Topic
Cardiovascular diseases are the leading cause of death worldwide and present a major financial burden to society. Posttranslational modifications (PTMs) are enzymatically catalyzed alterations of synthesized proteins at single or multiple amino acid levels, which may subsequently induce conformational changes and thus lead to changes in protein activity. PTMs are reversible processes that can add a chemical group or a small protein to a target protein, or remove them from a target protein. PTMs play an important role in mediating protein activity and thus are potentially involved in a variety of disease initiation, development, and treatment.
This Research Topic aims to collect articles that feature the importance of PTMs in the development, diagnosis, prognosis, and treatment of cardiovascular diseases. Phosphorylation is the most common PTM, while other PTMs, such as sumoylation, neddylation, and Ufm1 modification, have emerged as important regulators of cardiovascular homeostasis and diseases in recent years. As versatile functional mediators of a variety of proteins, it is conceivable that PTMs regulate a spectrum of signal transduction pathways and molecules that are implicated in cardiovascular disorders. We anticipate that the articles to be collected in this special edition will reflect the most recent advances in this field and present novel insights into mechanisms of related disease development and/or potential for translational medicine.
This collection welcomes Original Research, Review, Mini Review, and Perspectives on the advancement in the contribution of PTMs, which include but are not limited to phosphorylation, methylation, acetylation, sumoylation, glycosylation, ubiquitination, and neddylation, to the development, diagnosis, prognosis, and treatment of cardiovascular diseases. Areas of interest include, but are not limited to:
• PTMs in congenital heart defects;
• PTMs in myocardial infarction and cardiac regeneration;
• PTMs in dilated cardiomyopathy;
• PTMs in hypertrophic cardiomyopathy;
• PTMs in heart failure;
• PTMs in atherosclerosis;
• PTMs in arrhythmias;
Keywords: posttranslational modification, heart disease, vascular disease, signal transduction, protein stability, protein-protein interaction
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
