Protein Metabolism in Fungal Infection and Diseases

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Background

As highly complicated macromolecules, proteins are present in all living organisms and are essential for various biochemical processes. The synthesis, post-translational modification (e.g., glycosylation, phosphorylation, acetylation), and degradation (e.g., the ubiquitin-proteasome system and autophagy) of proteins are not only essential for primary and secondary metabolism but also play essential roles in the morphological development, pathogenicity, pathogen-host interaction and drug resistance of fungal pathogens. In recent decades, with the increase of population with HIV/AIDS or who have received organ transplants and immunosuppressive therapy, fungal pathogens, mainly including Cryptococcus neoformans, Aspergillus fumigatus, and Candida albicans, have infected over 150 million people and led to millions of deaths each year. Therefore, the diagnosis and treatment of fungal infections has become a big challenge, which in turn forces us to better understand the mechanisms that lead to fungal infection and disease to address this challenge. The purpose of this Research Topic is to seek submissions to further our understanding of the mechanisms by which protein metabolic pathways regulate fungal development, infection, pathogenesis, and drug resistance.

In this Research Topic, we aim to put together a collection of articles (Original Research Articles, Reviews, and Perspectives) that can contribute to our understanding of the role of molecules or signaling pathways associated with protein metabolism in fungal infection and diseases. We welcome studies about the role of protein synthesis, protein modification, and protein degradation in fungal development, infection, pathogenesis, pathogen-host interaction, immune responses, and drug resistance. To be more specific:

• Molecules or signalling pathways involved in protein modification for fungal development, interaction with host and host immunity
• Protein metabolism for secreting of fungal toxins or virulence factors
• Protein homeostasis for fungal survival and environmental stress adaptation
• New tools to study protein modification and degradation in fungal pathogens
• Application of protein metabolism in antifungal drug development and mycoses treatment
• All other aspects involved in protein metabolism that impacts fungal pathogenesis or host immune response

Keywords: human fungal pathogens, protein metabolism, pathogenesis, pathogen-host interaction, antifungal resistance

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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