About this Research Topic
Acute exacerbation of chronic rhinosinusitis (AECRS) has been recognized as an important disease entity with a significant impact on quality of life. Actually, patients with chronic rhinosinusitis usually exhibit alternations of stable phase and acute exacerbation. The treatment options regarding these two phases are obviously different based on the current guidelines and consensus. It should be pointed out that an acute exacerbation is defined as an acute and transient worsening of pre-existing symptoms in patients with CRS. This definition is largely subjective, and objective biomarkers are urgently needed. Current evidence supports the role of microbial dysbiosis and eosinophilic inflammation in the pathogenesis of AECRS. However, the precise etiology of AECRS is still unclear and is likely to be multifactorial. A variety of causes may deteriorate the clinical stability of patients with CRS including aerobic bacteria, viruses, cold temperature, air pollution and worsening of comorbidities. Although short-term oral antibiotics or oral steroids are suggested for AECRS, evidence-based treatment recommendations for AECRS are still lacking and large-high-quality RCTs are needed. The main goal of treatment during the stable phase might be the prevention of the exacerbation and achievement of the disease control.
Translational research about AECRS is limited by heterogeneity in methodological approach, including definitions of acute exacerbation, biomarkers and appropriate assessment methods. This Research Topic is focused on developing the diagnostic definition of the AECRS, characterizing the phenotypes of AECRS, building on the subjective biomarkers of the acute exacerbation, and exploring the etiology and pathophysiological mechanism of AECRS. These research will contribute to the consensus definition of AECRS, facilitate the design of clinical trials, and finally lead us to evidence-based treatment recommendations.
We welcome submissions of Original Research, Review and Mini Review on the sub-topics below:
• Consensus definition of acute exacerbation of chronic rhinosinusitis (AECRS)
• Diagnostic criteria based on subjective biomarkers
• Predisposing factors (allergy, infection, microbial dysfunction, etc.)
• Bacterial and or viral infection in the pathogenesis of AECRS
• Antimicrobial resistance and the related pathogens in patients with CRS/AECRS
• Evidence-based treatment options
Translational research about AECRS is limited by heterogeneity in methodological approach, including definitions of acute exacerbation, biomarkers and appropriate assessment methods. This Research Topic is focused on developing the diagnostic definition of the AECRS, characterizing the phenotypes of AECRS, building on the subjective biomarkers of the acute exacerbation, and exploring the etiology and pathophysiological mechanism of AECRS. These research will contribute to the consensus definition of AECRS, facilitate the design of clinical trials, and finally lead us to evidence-based treatment recommendations.
We welcome submissions of Original Research, Review and Mini Review on the sub-topics below:
• Consensus definition of acute exacerbation of chronic rhinosinusitis (AECRS)
• Diagnostic criteria based on subjective biomarkers
• Predisposing factors (allergy, infection, microbial dysfunction, etc.)
• Bacterial and or viral infection in the pathogenesis of AECRS
• Antimicrobial resistance and the related pathogens in patients with CRS/AECRS
• Evidence-based treatment options
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
