Myocardial Remodeling: Mechanisms and Translational Implications, Volume I

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Background

This Research Topic is part of a series with:
Myocardial Remodeling: Mechanisms and Translational Implications: Volume II

Cardiac remodeling, a precursor of clinical heart failure (HF), refers to the structural and functional reorganization of the left ventricle in response to pathogenic risk factors or internal or external cardiovascular damage. Left ventricular remodeling is a complex process involving cardiomyocyte growth and death, fibrosis, inflammation, and abnormal metabolism. As these events are highly inter-connected, targeting one single remodeling component may not be sufficient. Therefore, improving our understanding of the cellular and molecular basis of interrelated components of cardiac remodeling will help in developing strategic therapeutic interventions to enhance patient benefit in the future. There is currently no effective therapy to limit the pathological cardiac remodeling in HF progression.

This Research Topic focuses on the cellular and molecular components of aberrant tissue remodeling and emerging strategies to target cardiac hypertrophy, apoptosis, fibrosis, inflammation and metabolic abnormalities. Some of which could introduce novel therapeutic perspectives in heart disease, adding new elements for the development of novel multi-target-directed drug candidates for the treatment of HF. The goal of this Research Topic is to understand how aberrant cardiac remodeling contributes to the development and progression of HF and how to exploit this knowledge for therapeutic benefits to improve cardiac function and to prevent HF progression.

Myocyte hypertrophy, cellular necrosis, apoptosis, activation of cardiac fibroblasts and interstitial fibrosis, inflammation and abnormal energy metabolism are the major aspects of myocardial remodeling. Each of these inter-related components of the remodeling process contributes importantly to the development and progression of HF. We welcome high-quality manuscripts on advanced research in vivo and in vitro at functional and molecular levels with use of both physiological and pharmacological approaches to evaluate experimental and clinical perspectives to combat adverse cardiac remodeling. Topics of interest include, but are not limited to:
- Prevention and treatment options for aberrant cardiac cell remodeling
- The molecular mechanisms driving myocardial remodeling processes including hypertrophy, apoptosis, fibrosis, inflammation and energy metabolism
- The role of cardiac remodeling in the pathogenesis of the HF and its pathophysiological mechanisms in cardiovascular diseases
- The correlations between myocardial remodeling components and left ventricular performance during the development of HF

Keywords: hypertrophy, inflammation, fibrosis, energy metabolism, cardiac remodeling

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