About this Research Topic
Aside from small molecules targeted to manipulate splice factors and their kinases, there is a growing field novel therapeutics using antisense approaches to correct aberrant splicing.
This is a perfect time to produce a special issue that is focused on understanding the function and targetability of the vast array of proteins and ncRNAs that mediate pre-mRNA splicing and that regulate alternative splicing. One strand of the special issue will be the involvement of the pre-mRNA splicing machinery, splice factors (including ncRNAs), and splice factor kinases in disease processes and, in parallel, the exploration of novel therapeutic approaches that target them. Another strand will be, in line with the focus of the journal, to explore the function, expression and evolution of these molecules not only in mammals, but also in invertebrates, plants etc i.e. across the taxa.
We welcome submissions on the following subtopics:
· Developmental and physiological roles of all splice factors and splice factor kinases across taxa
· The regulation of their expression
· Evolutionary biology of splice factors and splice factor kinases
· Their biochemistry, substrates, and mechanism of action
· The roles of splice factors and splice factor kinases in all hallmarks of cancer
· Their roles in diseases other than cancer
· The development of potential pharmacological agents (including small molecules and antisense approaches) that target spliceosome components, splice factors and splice factor kinases
Both research articles and reviews are welcome
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.