About this Research Topic
Craniofacial and neurodevelopmental disorders are among the top causes of death and burden to patients, families and societies worldwide. Despite advances in gene variant discovery with the use of new sequencing technology, addressing the mechanisms by which genetic and/or epigenetic variants lead to phenotypic outcome remains challenging. To dissect disease mechanisms, interaction between the fields of Human Genetics and Cell/Developmental Biology is crucial, yet, oftentimes limited. The goal of this Research Topic is to further bridge the gap between these disciplines by bringing together research that contributes to the understanding of disease pathology through investigation of cellular and/or developmental mechanisms, with particular focus on craniofacial and neurodevelopmental disorders.
This collection welcomes research on the cellular/developmental processes associated with craniofacial or neurodevelopmental disorders. Article types may include, but are not limited to Original Research, Methods, Reviews or Perspectives, involving disease-relevant cell lines, animal models or other methods to bring forward novel insights into the etiology of these conditions. We also welcome insights into the ontogenetic link between craniofacial and nervous system development, which is a growing field of interest and may underpin several genetic conditions in which both processes are affected.
The articles may include the following topics:
-Mechanisms of development, including cell growth, migration, differentiation, specification and patterning
-Disease modeling with cellular and/or animal models
-Epigenetics/epigenomics
-Gene-environment interactions and their effects on development
-Maternal-fetal interface during development
-Development or improvement of disease models
-Possibilities for treatment and prevention
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.