Towards Integrated Approaches to Testing and Assessment (IATA) for Endocrine Disruptors - Maximizing Mechanistic Knowledge for Regulatory Purposes

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ORIGINAL RESEARCH

Published on 21 Mar 2022

Tentative Application of a Streamlined Protocol to Determine Organ-Specific Regulations of Deiodinase 1 and Dehalogenase Activities as Readouts of the Hypothalamus-Pituitary-Thyroid-Periphery-Axis

Kostja Renko
Helena Kerp
Janina Pape
Eddy Rijntjes
Tanja Burgdorf
Dagmar Führer
Josef Köhrle

Tentative Application of a Streamlined Protocol to Determine Organ-Specific Regulations of Deiodinase 1 and Dehalogenase Activities as Readouts of the Hypothalamus-Pituitary-Thyroid-Periphery-Axis

doi 10.3389/ftox.2022.822993

1,698 views
5 citations

OPINION

Published on 19 Jan 2022

Regulatory Testing for Endocrine Disruptors; Need for Validated Methods and Integrated Approaches

Elise Grignard
Kelly de Jesus
Philippe Hubert

Regulatory Testing for Endocrine Disruptors; Need for Validated Methods and Integrated Approaches

doi 10.3389/ftox.2021.821736

2,812 views
7 citations

PERSPECTIVE

Published on 21 Dec 2021

Evidenced-Based Approaches to Support the Development of Endocrine-Mediated Adverse Outcome Pathways: Challenges and Opportunities

Karine Audouze
Elias Zgheib
Khaled Abass
Asma H. Baig
Isabel Forner-Piquer
Henrik Holbech
Dries Knapen
Pim E. G. Leonards
Diana I. Lupu
3 more
Olwenn V. Martin

Evidenced-Based Approaches to Support the Development of Endocrine-Mediated Adverse Outcome Pathways: Challenges and Opportunities

doi 10.3389/ftox.2021.787017

3,019 views
8 citations

METHODS

Published on 15 Oct 2021

Development of the SciRAP Approach for Evaluating the Reliability and Relevance of in vitro Toxicity Data

Nicolas Roth
Johanna Zilliacus
Anna Beronius

Development of the SciRAP Approach for Evaluating the Reliability and Relevance of in vitro Toxicity Data

doi 10.3389/ftox.2021.746430

5,587 views
25 citations

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