About this Research Topic
Although many antibiotics have been discovered and applied into clinical treatment, bacterial infection remains a cause of high morbidity and mortality in many patients, especially in those who are immunocompromised. Bacteria infect humans via two major weapons, virulence factors and resistance to anti-microbial agents. Both are sophisticatedly controlled by the genes of bacteria.
Many genes related to antimicrobial resistance and virulence are constitutively expressed in the bacteria, but most of them are not fully expressed. Many factors influence the genes transcription and translation, including promoters of DNA, small RNAs, and regulator proteins such as Hfq protein. The small RNAs and related proteins form an RNA-protein complex, termed the RNA-induced silencing complex (RISC), which could block some specific mRNAs and inhibit the translation, and the Hfq protein is one of proteins forming RISCs. The gene regulation systems control the virulence and drug resistance of bacteria, which are related to the outcome of patients.
This Research Topic will collect studies about the factors which control the gene expression, including the transcription and translation. And describe the relationship between the gene control factor and the virulence of bacteria, as well as the resistance to antimicrobial agents. We wish to establish the pathway of gene expression and to discover the main (or novel) key factors of bacterial virulence or antimicrobial resistance.
The Research Topic includes, but is not limited to studies (including original article, perspectives, minireviews, commentaries, and opinion papers) that investigate and discuss:
1. The role of the promoters of DNA in the bacterial virulence or antimicrobial resistance
2. Studies about small RNAs and the association between small RNAs and mRNA-mediated translation.
3. The Key factor proteins which are activators or inhibitors of transcription and translation.
4. The Antagonist to the Key factor proteins, for example, the Hfq protein. We hope the antagonist will suppress the virulence of bacteria.
Many genes related to antimicrobial resistance and virulence are constitutively expressed in the bacteria, but most of them are not fully expressed. Many factors influence the genes transcription and translation, including promoters of DNA, small RNAs, and regulator proteins such as Hfq protein. The small RNAs and related proteins form an RNA-protein complex, termed the RNA-induced silencing complex (RISC), which could block some specific mRNAs and inhibit the translation, and the Hfq protein is one of proteins forming RISCs. The gene regulation systems control the virulence and drug resistance of bacteria, which are related to the outcome of patients.
This Research Topic will collect studies about the factors which control the gene expression, including the transcription and translation. And describe the relationship between the gene control factor and the virulence of bacteria, as well as the resistance to antimicrobial agents. We wish to establish the pathway of gene expression and to discover the main (or novel) key factors of bacterial virulence or antimicrobial resistance.
The Research Topic includes, but is not limited to studies (including original article, perspectives, minireviews, commentaries, and opinion papers) that investigate and discuss:
1. The role of the promoters of DNA in the bacterial virulence or antimicrobial resistance
2. Studies about small RNAs and the association between small RNAs and mRNA-mediated translation.
3. The Key factor proteins which are activators or inhibitors of transcription and translation.
4. The Antagonist to the Key factor proteins, for example, the Hfq protein. We hope the antagonist will suppress the virulence of bacteria.
Keywords: Promotor, transcription, translation, messenger RNA, small RNA, RNA-induced silencing complex, Hfq protein, bacterial virulence, antimicrobial resistance
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