About this Research Topic
For this Research Topic, we would like to create a forum for studies on the prediction of clinical outcomes of ACLF. This includes studies on how it evolves during the natural history and the major risk factors that shape disease outcomes, as well as identification of the optimal prognostic model among available ones and development of novel tools to improve the accuracy. We would also like to bring together recent advances in the development of novel therapies for ACLF. This includes elucidating the underlying mechanisms from multifaceted perspectives using animal models or biosamples of patients that would lead to the discovery of potential therapeutic targets, as well as evaluating the efficacy and safety of emerging therapies such as artificial liver supporting, cell therapy, and GM-CSF therapies.
We welcome submissions of Original Research, Brief Research Report, and Review articles covering (but not limited to) the following aspects:
• To characterize the natural history of ACLF including the precipitants, clinical course, complications, risk factors, short-term and long-term outcomes. (clinical studies)
• To investigate underlying uncontrolled hepatic and systemic inflammation of ACLF from aspects of virology, immunology, genome, transcriptome, epigenome, metabolism, and microbiome that leads to the identification of potential biomarkers or therapeutical targets. (basic or translational studies)
• To develop clinical models or biomarker-guiding models to accurately predict the short-term outcome of ACLF. (clinical or translational studies)
• To evaluate the efficacy and safety of emerging therapies such as artificial liver supporting systems, cell therapy, and GM-CSF therapies, and so on. (clinical studies)
Keywords: Viral hepatitis, acute-on-chronic liver failure, natural history, pathogenesis, treatment
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.