About this Research Topic
There are complex transcriptomes in the eyes, including a vast number of non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long ncRNAs (lncRNAs), circular RNAs (circRNAs), tRNA-derived small RNAs (tsRNAs), etc. In a range of ophthalmic diseases, such as glaucoma, cataract, myopia and retinal diseases, a significant shift in the expression pattern of ncRNAs was observed in numerous studies. In addition, in these ophthalmic diseases, ncRNAs have been shown to play an important role in pathogenesis. The genetic landscape and regulatory networks composed of ncRNAs in ophthalmic diseases still remain enigmatic.
Although without the capability of protein-coding, the activation of ncRNAs through sophisticated mechanisms could regulate protein-coding genes. As a molecular sponge, for example, lncRNA/circRNA regulates the functions and expression of certain mRNA by targeting specific miRNAs, this mechanism is widely investigated as competing endogenous RNA (ceRNA). In addition, many studies have shown that ncRNAs participate in protein binding and epigenetic modification. Non-coding RNAs are considered as potential diagnostic biomarkers and therapeutic targets of refractory ophthalmic diseases.
The goal of this research topic is by exploring the roles, molecular mechanism, and potential applications of ncRNAs to eventually reveal the regulatory networks composed of ncRNAs and key elements in ophthalmic diseases.
Submissions of research articles or academic reviews focusing on ncRNAs in ophthalmic diseases are welcomed. Potential subjects include the following, but are not restricted to:
-The function of ncRNAs as epigenetic regulators in ophthalmic disease pathogenesis
-The regulatory network of various ncRNAs in ophthalmic diseases
-NcRNAs as potential diagnosis and prognosis biomarkers in ophthalmic diseases
-Participation of ncRNAs in ophthalmic diseases by bioinformatic analysis
-Translational study and application of ncRNAs in ophthalmic disease therapy
Although without the capability of protein-coding, the activation of ncRNAs through sophisticated mechanisms could regulate protein-coding genes. As a molecular sponge, for example, lncRNA/circRNA regulates the functions and expression of certain mRNA by targeting specific miRNAs, this mechanism is widely investigated as competing endogenous RNA (ceRNA). In addition, many studies have shown that ncRNAs participate in protein binding and epigenetic modification. Non-coding RNAs are considered as potential diagnostic biomarkers and therapeutic targets of refractory ophthalmic diseases.
The goal of this research topic is by exploring the roles, molecular mechanism, and potential applications of ncRNAs to eventually reveal the regulatory networks composed of ncRNAs and key elements in ophthalmic diseases.
Submissions of research articles or academic reviews focusing on ncRNAs in ophthalmic diseases are welcomed. Potential subjects include the following, but are not restricted to:
-The function of ncRNAs as epigenetic regulators in ophthalmic disease pathogenesis
-The regulatory network of various ncRNAs in ophthalmic diseases
-NcRNAs as potential diagnosis and prognosis biomarkers in ophthalmic diseases
-Participation of ncRNAs in ophthalmic diseases by bioinformatic analysis
-Translational study and application of ncRNAs in ophthalmic disease therapy
Keywords: Non-coding RNA, genetic regulation, transcriptome, competing endogenous RNA, ophthalmic disease, eye
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