Adverse Outcome Pathways and New Approach Methodologies: Evolution, Opportunities, and Challenges

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ORIGINAL RESEARCH

Published on 15 Jun 2022

Mapping Adverse Outcome Pathways for Kidney Injury as a Basis for the Development of Mechanism-Based Animal-Sparing Approaches to Assessment of Nephrotoxicity

Angela Mally
Sebastian Jarzina

doi 10.3389/ftox.2022.863643

2,439 views
3 citations

ORIGINAL RESEARCH

Published on 28 Apr 2022

A Case Study on Integrating a New Key Event Into an Existing Adverse Outcome Pathway on Oxidative DNA Damage: Challenges and Approaches in a Data-Rich Area

Elizabeth Huliganga
Francesco Marchetti
Jason M. O’Brien
Vinita Chauhan
Carole L. Yauk

doi 10.3389/ftox.2022.827328

2,089 views
2 citations

ORIGINAL RESEARCH

Published on 19 Apr 2022

Application of the Adverse Outcome Pathway Concept to In Vitro Nephrotoxicity Assessment: Kidney Injury due to Receptor-Mediated Endocytosis and Lysosomal Overload as a Case Study

Sebastian Jarzina
Stefano Di Fiore
Bernhard Ellinger
Pia Reiser
Sabrina Frank
Markus Glaser
Jiaqing Wu
Femke J. Taverne
Nynke I. Kramer
Angela Mally

doi 10.3389/ftox.2022.864441

7,234 views
5 citations

PERSPECTIVE

Published on 30 Mar 2022

From Qualitative to Quantitative AOP: A Case Study of Neurodegeneration

Dennis Sinitsyn
Natàlia Garcia-Reyero
Karen H. Watanabe

doi 10.3389/ftox.2022.838729

2,043 views
2 citations

ORIGINAL RESEARCH

Published on 24 Mar 2022

Integration of Adverse Outcome Pathways, Causal Networks and ‘Omics to Support Chemical Hazard Assessment

Edward J. Perkins
E. Alice Woolard
Natàlia Garcia-Reyero

doi 10.3389/ftox.2022.786057

2,072 views
8 citations

ORIGINAL RESEARCH

Published on 07 Mar 2022

Mapping Mechanistic Pathways of Acute Oral Systemic Toxicity Using Chemical Structure and Bioactivity Measurements

Stephen W. Edwards
Mark Nelms
Virginia K. Hench
Jessica Ponder
Kristie Sullivan

doi 10.3389/ftox.2022.824094

2,523 views
4 citations

ORIGINAL RESEARCH

Published on 07 Mar 2022

Beyond AOPs: A Mechanistic Evaluation of NAMs in DART Testing

Ramya Rajagopal
Maria T. Baltazar
Paul L. Carmichael
Matthew P. Dent
Julia Head
Hequn Li
Iris Muller
Joe Reynolds
Kritika Sadh
3 more
Predrag Kukic

doi 10.3389/ftox.2022.838466

8,261 views
21 citations

ORIGINAL RESEARCH

Published on 07 Mar 2022

From Causal Networks to Adverse Outcome Pathways: A Developmental Neurotoxicity Case Study

Živa Ramšak
Vid Modic
Roman A. Li
Colette vom Berg
Anze Zupanic

doi 10.3389/ftox.2022.815754

3,865 views
6 citations

ORIGINAL RESEARCH

Published on 19 Jan 2022

Exploration of the DARTable Genome- a Resource Enabling Data-Driven NAMs for Developmental and Reproductive Toxicity Prediction

Elzbieta I. Janowska-Sejda
Yeyejide Adeleye
Richard A. Currie

doi 10.3389/ftox.2021.806311

2,877 views
5 citations

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Articles

Mapping Adverse Outcome Pathways for Kidney Injury as a Basis for the Development of Mechanism-Based Animal-Sparing Approaches to Assessment of Nephrotoxicity

A Case Study on Integrating a New Key Event Into an Existing Adverse Outcome Pathway on Oxidative DNA Damage: Challenges and Approaches in a Data-Rich Area

Application of the Adverse Outcome Pathway Concept to In Vitro Nephrotoxicity Assessment: Kidney Injury due to Receptor-Mediated Endocytosis and Lysosomal Overload as a Case Study

From Qualitative to Quantitative AOP: A Case Study of Neurodegeneration

Integration of Adverse Outcome Pathways, Causal Networks and ‘Omics to Support Chemical Hazard Assessment

Mapping Mechanistic Pathways of Acute Oral Systemic Toxicity Using Chemical Structure and Bioactivity Measurements

Beyond AOPs: A Mechanistic Evaluation of NAMs in DART Testing

From Causal Networks to Adverse Outcome Pathways: A Developmental Neurotoxicity Case Study

Exploration of the DARTable Genome- a Resource Enabling Data-Driven NAMs for Developmental and Reproductive Toxicity Prediction

Frontiers in Toxicology

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