About this Research Topic
RNA-mediated epigenetic regulations play an important role in development and diseases. Numerous chromatin-binding proteins have been reported to interact with and be regulated by RNA, but the molecular details and functional importance of these interactions frequently remain unanswered. These regulations include regulation of higher-order chromatin architecture, nucleosome positioning, phase separation, heterochromatin formation, and other nuclear processes.
The goal is to understand the functional importance of RNA in epigenetic regulation, with an emphasis on the mechanistic aspect of the regulation. Numerous chromatin-binding proteins are reported to interact with and/or be regulated by RNA, but the molecular basis and functional importance frequently remain unanswered. Understanding functions and mechanisms has been challenging due to the lack of canonical RNA-binding domains.
All article types are welcome. Specific themes of interest include, but are not limited to:
[1] the role(s) of distinct classes of RNA (lncRNAs, small RNAs, mRNA, etc.) and their modification or editing forms in:
- regulation of chromatin-binding proteins (epigenetic modifiers, chromatin remodelers, transcription factors, etc.)
- chromatin structure (i.e., 3D genomics, nucleosome positioning)
- heterochromatin formation
- phase separation
- the role of RNA splicing in chromatin regulation
- cellular differentiation (i.e., cell fate determination)
- clinical and disease relevance of RNA-mediated epigenetic regulation
[2] how chromatin modifications regulate RNA processing
The goal is to understand the functional importance of RNA in epigenetic regulation, with an emphasis on the mechanistic aspect of the regulation. Numerous chromatin-binding proteins are reported to interact with and/or be regulated by RNA, but the molecular basis and functional importance frequently remain unanswered. Understanding functions and mechanisms has been challenging due to the lack of canonical RNA-binding domains.
All article types are welcome. Specific themes of interest include, but are not limited to:
[1] the role(s) of distinct classes of RNA (lncRNAs, small RNAs, mRNA, etc.) and their modification or editing forms in:
- regulation of chromatin-binding proteins (epigenetic modifiers, chromatin remodelers, transcription factors, etc.)
- chromatin structure (i.e., 3D genomics, nucleosome positioning)
- heterochromatin formation
- phase separation
- the role of RNA splicing in chromatin regulation
- cellular differentiation (i.e., cell fate determination)
- clinical and disease relevance of RNA-mediated epigenetic regulation
[2] how chromatin modifications regulate RNA processing
Keywords: RNA, epigenetics, transcription, chromatin-binding proteins, RNA-binding proteins, splicing, phase separation, RNA modifications
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