About this Research Topic
The goal is to understand the functional importance of RNA in epigenetic regulation, with an emphasis on the mechanistic aspect of the regulation. Numerous chromatin-binding proteins are reported to interact with and/or be regulated by RNA, but the molecular basis and functional importance frequently remain unanswered. Understanding functions and mechanisms has been challenging due to the lack of canonical RNA-binding domains.
All article types are welcome. Specific themes of interest include, but are not limited to:
[1] the role(s) of distinct classes of RNA (lncRNAs, small RNAs, mRNA, etc.) and their modification or editing forms in:
- regulation of chromatin-binding proteins (epigenetic modifiers, chromatin remodelers, transcription factors, etc.)
- chromatin structure (i.e., 3D genomics, nucleosome positioning)
- heterochromatin formation
- phase separation
- the role of RNA splicing in chromatin regulation
- cellular differentiation (i.e., cell fate determination)
- clinical and disease relevance of RNA-mediated epigenetic regulation
[2] how chromatin modifications regulate RNA processing
Keywords: RNA, epigenetics, transcription, chromatin-binding proteins, RNA-binding proteins, splicing, phase separation, RNA modifications
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